BRD-K88198340_2-(6,6-dimethoxy-3-oxocyclohexa-1,4-dienylcarbamoyl)phenyl acetate GNFk-3_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K88198340_2-(6,6-dimethoxy-3-oxocyclohexa-1,4-dienylcarbamoyl)phenyl acetate GNFk-3_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
APOA2 apolipoprotein A-II
BAMBI BMP and activin membrane-bound inhibitor
BMP7 bone morphogenetic protein 7
BPHL biphenyl hydrolase-like (serine hydrolase)
CEMIP cell migration inducing protein, hyaluronan binding
DDAH1 dimethylarginine dimethylaminohydrolase 1
DKK4 dickkopf WNT signaling pathway inhibitor 4
DSP desmoplakin
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GDF15 growth differentiation factor 15
GPX2 glutathione peroxidase 2
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL1R2 interleukin 1 receptor, type II
LBP lipopolysaccharide binding protein
LGALS4 lectin, galactoside-binding, soluble, 4
MICALL1 MICAL-like 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
S100P S100 calcium binding protein P
SERTAD2 SERTA domain containing 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPHK1 sphingosine kinase 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
TES testin LIM domain protein
TKT transketolase
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIRF adipogenesis regulatory factor
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
AKAP12 A kinase (PRKA) anchor protein 12
ANO1 anoctamin 1, calcium activated chloride channel
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
BCL2A1 BCL2-related protein A1
C2CD5 C2 calcium-dependent domain containing 5
C3 complement component 3
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAV1 caveolin 1, caveolae protein, 22kDa
CCL4 chemokine (C-C motif) ligand 4
CD200 CD200 molecule
CDK1 cyclin-dependent kinase 1
COL13A1 collagen, type XIII, alpha 1
COL1A2 collagen, type I, alpha 2
CSTA cystatin A (stefin A)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DCK deoxycytidine kinase
DDB2 damage-specific DNA binding protein 2, 48kDa
DLD dihydrolipoamide dehydrogenase
DMXL2 Dmx-like 2
DUSP4 dual specificity phosphatase 4
FAM129A family with sequence similarity 129, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
G0S2 G0/G1 switch 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GZMK granzyme K (granzyme 3; tryptase II)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGA2 high mobility group AT-hook 2
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICMT isoprenylcysteine carboxyl methyltransferase
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
KIAA0101 KIAA0101
KRT7 keratin 7, type II
KRT81 keratin 81, type II
LAMA3 laminin, alpha 3
LAMB1 laminin, beta 1
LIPA lipase A, lysosomal acid, cholesterol esterase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MXRA5 matrix-remodelling associated 5
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NELL2 NEL-like 2 (chicken)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR2F1 nuclear receptor subfamily 2, group F, member 1
NT5E 5'-nucleotidase, ecto (CD73)
PBX1 pre-B-cell leukemia homeobox 1
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLA2G16 phospholipase A2, group XVI
PLIN1 perilipin 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCH protein kinase C, eta
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
RPL37A ribosomal protein L37a
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SFRP1 secreted frizzled-related protein 1
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
STC1 stanniocalcin 1
STMN1 stathmin 1
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
WFDC2 WAP four-disulfide core domain 2
ZBED2 zinc finger, BED-type containing 2
Funding