BRD-K88278225_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

198 genes differentially expressed following the BRD-K88278225_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
AK5 adenylate kinase 5
ARHGAP29 Rho GTPase activating protein 29
BCAM basal cell adhesion molecule (Lutheran blood group)
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
BID BH3 interacting domain death agonist
C1ORF115 chromosome 1 open reading frame 115
C3 complement component 3
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCL5 chemokine (C-C motif) ligand 5
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
CP ceruloplasmin (ferroxidase)
CPB1 carboxypeptidase B1 (tissue)
CRABP2 cellular retinoic acid binding protein 2
CREM cAMP responsive element modulator
CRYM crystallin, mu
CTSZ cathepsin Z
DAXX death-domain associated protein
DEFA4 defensin, alpha 4, corticostatin
DENND2D DENN/MADD domain containing 2D
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DPP4 dipeptidyl-peptidase 4
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP5 dual specificity phosphatase 5
EIF5A eukaryotic translation initiation factor 5A
ELANE elastase, neutrophil expressed
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPAS1 endothelial PAS domain protein 1
EPS8L1 EPS8-like 1
ERBB4 erb-b2 receptor tyrosine kinase 4
EXT1 exostosin glycosyltransferase 1
EZR ezrin
FAM46C family with sequence similarity 46, member C
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GNLY granulysin
HBB hemoglobin, beta
HBD hemoglobin, delta
HBE1 hemoglobin, epsilon 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
IGLV2-23 immunoglobulin lambda variable 2-23
ISYNA1 inositol-3-phosphate synthase 1
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
JUP junction plakoglobin
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT18 keratin 18, type I
LDOC1 leucine zipper, down-regulated in cancer 1
LXN latexin
LYZ lysozyme
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MBTPS1 membrane-bound transcription factor peptidase, site 1
MPO myeloperoxidase
MTSS1 metastasis suppressor 1
MUC16 mucin 16, cell surface associated
NELL2 NEL-like 2 (chicken)
NNMT nicotinamide N-methyltransferase
NRGN neurogranin (protein kinase C substrate, RC3)
NTS neurotensin
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
PDE4B phosphodiesterase 4B, cAMP-specific
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PLBD1 phospholipase B domain containing 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
QPCT glutaminyl-peptide cyclotransferase
RAB20 RAB20, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
REEP5 receptor accessory protein 5
SCGB1D2 secretoglobin, family 1D, member 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SOD2 superoxide dismutase 2, mitochondrial
SORBS2 sorbin and SH3 domain containing 2
SRGN serglycin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STAT4 signal transducer and activator of transcription 4
STC2 stanniocalcin 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TM4SF1 transmembrane 4 L six family member 1
TMEM110 transmembrane protein 110
TMEM246 transmembrane protein 246
TMSB15A thymosin beta 15a
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPD52L1 tumor protein D52-like 1
TRD T cell receptor delta locus
TSPAN12 tetraspanin 12
TUBA4A tubulin, alpha 4a
USP1 ubiquitin specific peptidase 1
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
WT1 Wilms tumor 1
ZC3H12A zinc finger CCCH-type containing 12A

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AHNAK2 AHNAK nucleoprotein 2
AIM2 absent in melanoma 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA5 annexin A5
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BMP2 bone morphogenetic protein 2
C14ORF132 chromosome 14 open reading frame 132
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPRIN2 caprin family member 2
CELF2 CUGBP, Elav-like family member 2
CLIC4 chloride intracellular channel 4
CSRP2 cysteine and glycine-rich protein 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
EDNRB endothelin receptor type B
EIF5 eukaryotic translation initiation factor 5
ENO2 enolase 2 (gamma, neuronal)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM57A family with sequence similarity 57, member A
FERMT1 fermitin family member 1
FHL1 four and a half LIM domains 1
GOLGA8A golgin A8 family, member A
GPM6B glycoprotein M6B
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LYPLA1 lysophospholipase I
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MED1 mediator complex subunit 1
MFAP2 microfibrillar-associated protein 2
MLEC malectin
MSX1 msh homeobox 1
MYBPC1 myosin binding protein C, slow type
NAV2 neuron navigator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NIP7 NIP7, nucleolar pre-rRNA processing protein
PCDH9 protocadherin 9
PFN2 profilin 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLN phospholamban
PLP1 proteolipid protein 1
PLS3 plastin 3
PNMA2 paraneoplastic Ma antigen 2
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
SEH1L SEH1-like (S. cerevisiae)
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SORBS1 sorbin and SH3 domain containing 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
TFF3 trefoil factor 3 (intestinal)
TIMP3 TIMP metallopeptidase inhibitor 3
TRIM9 tripartite motif containing 9
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TYRP1 tyrosinase-related protein 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WSB1 WD repeat and SOCS box containing 1