BRD-K88510285_B675700.cdx_A549_24.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

164 genes differentially expressed following the BRD-K88510285_B675700.cdx_A549_24.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
C10ORF10 chromosome 10 open reading frame 10
CCL20 chemokine (C-C motif) ligand 20
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL2 chemokine (C-X-C motif) ligand 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EIF5 eukaryotic translation initiation factor 5
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FASTKD5 FAST kinase domains 5
FHL2 four and a half LIM domains 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOMER3 homer scaffolding protein 3
HOXB2 homeobox B2
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KRT23 keratin 23, type I
LAMB3 laminin, beta 3
LYPD3 LY6/PLAUR domain containing 3
MMP7 matrix metallopeptidase 7
MSX1 msh homeobox 1
MT1E metallothionein 1E
NPC1 Niemann-Pick disease, type C1
OSR2 odd-skipped related transciption factor 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PELI1 pellino E3 ubiquitin protein ligase 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSEN1 presenilin 1
PSME4 proteasome (prosome, macropain) activator subunit 4
QPCT glutaminyl-peptide cyclotransferase
RGS5 regulator of G-protein signaling 5
RIPK2 receptor-interacting serine-threonine kinase 2
RND3 Rho family GTPase 3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RTN2 reticulon 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SPON2 spondin 2, extracellular matrix protein
TACSTD2 tumor-associated calcium signal transducer 2
TFRC transferrin receptor
TIMP3 TIMP metallopeptidase inhibitor 3
TRIM2 tripartite motif containing 2
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
VWF von Willebrand factor
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADGRE5 adhesion G protein-coupled receptor E5
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANXA13 annexin A13
AURKB aurora kinase B
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
C1RL complement component 1, r subcomponent-like
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCDC92 coiled-coil domain containing 92
CCNA2 cyclin A2
CCNF cyclin F
CDK1 cyclin-dependent kinase 1
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
DCXR dicarbonyl/L-xylulose reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DYNLRB1 dynein, light chain, roadblock-type 1
ELOVL6 ELOVL fatty acid elongase 6
ENO2 enolase 2 (gamma, neuronal)
FAM216A family with sequence similarity 216, member A
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
FOXG1 forkhead box G1
GALE UDP-galactose-4-epimerase
GPX3 glutathione peroxidase 3
GSE1 Gse1 coiled-coil protein
GTF2H5 general transcription factor IIH, polypeptide 5
HACD1 3-hydroxyacyl-CoA dehydratase 1
HADH hydroxyacyl-CoA dehydrogenase
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF14 kinesin family member 14
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LIMCH1 LIM and calponin homology domains 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MMD monocyte to macrophage differentiation-associated
MSRB2 methionine sulfoxide reductase B2
MXRA7 matrix-remodelling associated 7
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NLRP2 NLR family, pyrin domain containing 2
NNMT nicotinamide N-methyltransferase
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NRGN neurogranin (protein kinase C substrate, RC3)
NRN1 neuritin 1
NTS neurotensin
PBLD phenazine biosynthesis-like protein domain containing
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PHYH phytanoyl-CoA 2-hydroxylase
PLK1 polo-like kinase 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRKCB protein kinase C, beta
PRSS2 protease, serine, 2 (trypsin 2)
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB20 RAB20, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RPA3 replication protein A3, 14kDa
S100A4 S100 calcium binding protein A4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC16A4 solute carrier family 16, member 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPP1 secreted phosphoprotein 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TCTN1 tectonic family member 1
TFF3 trefoil factor 3 (intestinal)
TM4SF4 transmembrane 4 L six family member 4
TMEM106B transmembrane protein 106B
TMEM47 transmembrane protein 47
TOB1 transducer of ERBB2, 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TSKU tsukushi, small leucine rich proteoglycan
TSPAN4 tetraspanin 4
TWF1 twinfilin actin binding protein 1
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UPK1B uroplakin 1B
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
ZMYND8 zinc finger, MYND-type containing 8
Funding