BRD-K88510285_B675700.cdx_HA1E_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-K88510285_B675700.cdx_HA1E_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACBD3 acyl-CoA binding domain containing 3
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANXA1 annexin A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CTH cystathionine gamma-lyase
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EDN1 endothelin 1
EIF5 eukaryotic translation initiation factor 5
FN1 fibronectin 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GATA3 GATA binding protein 3
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GLUL glutamate-ammonia ligase
GRB7 growth factor receptor-bound protein 7
HAPLN1 hyaluronan and proteoglycan link protein 1
HES1 hes family bHLH transcription factor 1
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
ITM2A integral membrane protein 2A
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
KCTD5 potassium channel tetramerization domain containing 5
KLHL21 kelch-like family member 21
KRT81 keratin 81, type II
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP7 matrix metallopeptidase 7
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NELL2 NEL-like 2 (chicken)
NPC1 Niemann-Pick disease, type C1
ORC1 origin recognition complex, subunit 1
OSER1 oxidative stress responsive serine-rich 1
PELI1 pellino E3 ubiquitin protein ligase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RPL10 ribosomal protein L10
RTN1 reticulon 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
SRGN serglycin
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
THBD thrombomodulin
TM6SF1 transmembrane 6 superfamily member 1
TRD T cell receptor delta locus
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UGDH UDP-glucose 6-dehydrogenase
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ALDOB aldolase B, fructose-bisphosphate
ATF5 activating transcription factor 5
AURKA aurora kinase A
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
BTBD3 BTB (POZ) domain containing 3
C2CD5 C2 calcium-dependent domain containing 5
CAPN3 calpain 3, (p94)
CCND1 cyclin D1
CDC25B cell division cycle 25B
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CETN3 centrin, EF-hand protein, 3
CLIC3 chloride intracellular channel 3
CPA3 carboxypeptidase A3 (mast cell)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSP desmoplakin
DUSP22 dual specificity phosphatase 22
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM111A family with sequence similarity 111, member A
FEN1 flap structure-specific endonuclease 1
FUCA1 fucosidase, alpha-L- 1, tissue
GINS1 GINS complex subunit 1 (Psf1 homolog)
GSPT2 G1 to S phase transition 2
GSTA4 glutathione S-transferase alpha 4
H2BFS H2B histone family, member S (pseudogene)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H2BK histone cluster 1, H2bk
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP3 insulin-like growth factor binding protein 3
ISG15 ISG15 ubiquitin-like modifier
JADE2 jade family PHD finger 2
KANK2 KN motif and ankyrin repeat domains 2
LAPTM4B lysosomal protein transmembrane 4 beta
LOXL1 lysyl oxidase-like 1
MAGEA3 melanoma antigen family A3
MATN2 matrilin 2
MCM2 minichromosome maintenance complex component 2
MFAP5 microfibrillar associated protein 5
MSH6 mutS homolog 6
NFIB nuclear factor I/B
NREP neuronal regeneration related protein
PCNA proliferating cell nuclear antigen
PEPD peptidase D
PI3 peptidase inhibitor 3, skin-derived
PLK1 polo-like kinase 1
PNMA2 paraneoplastic Ma antigen 2
PXDN peroxidasin
RHOBTB3 Rho-related BTB domain containing 3
SFN stratifin
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRR1A small proline-rich protein 1A
THY1 Thy-1 cell surface antigen
TMEM106B transmembrane protein 106B
TNS3 tensin 3
TYRP1 tyrosinase-related protein 1
UBE2C ubiquitin-conjugating enzyme E2C
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAN versican
ZBTB18 zinc finger and BTB domain containing 18
ZCCHC24 zinc finger, CCHC domain containing 24
Funding