BRD-K88510285_B675700.cdx_MDST8_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

167 genes differentially expressed following the BRD-K88510285_B675700.cdx_MDST8_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AZIN1 antizyme inhibitor 1
BAG3 BCL2-associated athanogene 3
C1QA complement component 1, q subcomponent, A chain
CA2 carbonic anhydrase II
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL5A2 collagen, type V, alpha 2
CSRP2 cysteine and glycine-rich protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPP4 dipeptidyl-peptidase 4
DSP desmoplakin
FAM129A family with sequence similarity 129, member A
FNBP1L formin binding protein 1-like
FTH1 ferritin, heavy polypeptide 1
GAB2 GRB2-associated binding protein 2
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GADD45A growth arrest and DNA-damage-inducible, alpha
HAPLN1 hyaluronan and proteoglycan link protein 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IFRD1 interferon-related developmental regulator 1
KRT81 keratin 81, type II
LRMP lymphoid-restricted membrane protein
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MEIS2 Meis homeobox 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTUS1 microtubule associated tumor suppressor 1
MUC16 mucin 16, cell surface associated
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
PTN pleiotrophin
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS2 regulator of G-protein signaling 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNX11 sorting nexin 11
SNX7 sorting nexin 7
SST somatostatin
TARS threonyl-tRNA synthetase
TMSB15A thymosin beta 15a
TNS1 tensin 1
TP53BP2 tumor protein p53 binding protein 2
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
ZBTB10 zinc finger and BTB domain containing 10
ZNF131 zinc finger protein 131
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALCAM activated leukocyte cell adhesion molecule
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APOD apolipoprotein D
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
B3GNT1
BAX BCL2-associated X protein
C8ORF4 chromosome 8 open reading frame 4
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNF cyclin F
CD47 CD47 molecule
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHSY1 chondroitin sulfate synthase 1
COG2 component of oligomeric golgi complex 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CYTL1 cytokine-like 1
DALRD3 DALR anticodon binding domain containing 3
DCBLD2 discoidin, CUB and LCCL domain containing 2
DUSP4 dual specificity phosphatase 4
EIF5B eukaryotic translation initiation factor 5B
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP3 epithelial membrane protein 3
ERBB2 erb-b2 receptor tyrosine kinase 2
EXOSC4 exosome component 4
F2R coagulation factor II (thrombin) receptor
FHL1 four and a half LIM domains 1
GALE UDP-galactose-4-epimerase
GRWD1 glutamate-rich WD repeat containing 1
HMG20B high mobility group 20B
HMGA2 high mobility group AT-hook 2
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
IFI6 interferon, alpha-inducible protein 6
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTBP3 latent transforming growth factor beta binding protein 3
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NMB neuromedin B
NOTCH2 notch 2
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
PBX3 pre-B-cell leukemia homeobox 3
PDGFC platelet derived growth factor C
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP prolactin-induced protein
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRAME preferentially expressed antigen in melanoma
PRSS23 protease, serine, 23
RPA3 replication protein A3, 14kDa
RPL39L ribosomal protein L39-like
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TNC tenascin C
ZMAT3 zinc finger, matrin-type 3
Funding