BRD-K88510285_B675700.cdx_NCIH1836_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-K88510285_B675700.cdx_NCIH1836_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACTN1 actinin, alpha 1
AKR1C3 aldo-keto reductase family 1, member C3
ANGPT1 angiopoietin 1
ARMCX3 armadillo repeat containing, X-linked 3
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BLMH bleomycin hydrolase
BTN3A2 butyrophilin, subfamily 3, member A2
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CP ceruloplasmin (ferroxidase)
CRYAB crystallin, alpha B
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATA3 GATA binding protein 3
GPX2 glutathione peroxidase 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
ITM2A integral membrane protein 2A
JMJD6 jumonji domain containing 6
KRT15 keratin 15, type I
LY75 lymphocyte antigen 75
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PALLD palladin, cytoskeletal associated protein
PITX1 paired-like homeodomain 1
PLBD1 phospholipase B domain containing 1
PLIN2 perilipin 2
PSAP prosaposin
QPCT glutaminyl-peptide cyclotransferase
RAD23B RAD23 homolog B (S. cerevisiae)
RCAN1 regulator of calcineurin 1
RHOB ras homolog family member B
RND3 Rho family GTPase 3
RPA2 replication protein A2, 32kDa
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAGP small cell adhesion glycoprotein
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
SYNM synemin, intermediate filament protein
SYT1 synaptotagmin I
TBC1D4 TBC1 domain family, member 4
TBXA2R thromboxane A2 receptor
TDO2 tryptophan 2,3-dioxygenase
TENM1 teneurin transmembrane protein 1
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TPST2 tyrosylprotein sulfotransferase 2
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAV3 vav 3 guanine nucleotide exchange factor
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
C7 complement component 7
CLDN18 claudin 18
CLIC5 chloride intracellular channel 5
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CPA3 carboxypeptidase A3 (mast cell)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DICER1 dicer 1, ribonuclease type III
FBN2 fibrillin 2
FBXO21 F-box protein 21
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GPC3 glypican 3
IFITM2 interferon induced transmembrane protein 2
LAMP3 lysosomal-associated membrane protein 3
MFSD10 major facilitator superfamily domain containing 10
NPEPL1 aminopeptidase-like 1
NTS neurotensin
PLAGL1 pleiomorphic adenoma gene-like 1
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PPOX protoporphyrinogen oxidase
PRDX2 peroxiredoxin 2
RAB2A RAB2A, member RAS oncogene family
RAD51C RAD51 paralog C
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
SCAND1 SCAN domain containing 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SLC16A6 solute carrier family 16, member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPON1 spondin 1, extracellular matrix protein
SRI sorcin
SST somatostatin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
WIF1 WNT inhibitory factor 1
WISP2 WNT1 inducible signaling pathway protein 2
Funding