BRD-K88510285_B675700.cdx_PC3_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

171 genes differentially expressed following the BRD-K88510285_B675700.cdx_PC3_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANKRD10 ankyrin repeat domain 10
ANKRD12 ankyrin repeat domain 12
ANOS1 anosmin 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG3 BTG family, member 3
CACYBP calcyclin binding protein
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CD99 CD99 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL3A1 collagen, type III, alpha 1
CPM carboxypeptidase M
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP2 dual specificity phosphatase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM53C family with sequence similarity 53, member C
FASTKD5 FAST kinase domains 5
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA2 heat shock 70kDa protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MFSD10 major facilitator superfamily domain containing 10
MICB MHC class I polypeptide-related sequence B
MINK1 misshapen-like kinase 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP7 matrix metallopeptidase 7
MSX1 msh homeobox 1
NDRG1 N-myc downstream regulated 1
NEFL neurofilament, light polypeptide
NQO1 NAD(P)H dehydrogenase, quinone 1
OSER1 oxidative stress responsive serine-rich 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PIR pirin (iron-binding nuclear protein)
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PKM pyruvate kinase, muscle
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RCAN1 regulator of calcineurin 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
SRGN serglycin
TDP2 tyrosyl-DNA phosphodiesterase 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPM4 tropomyosin 4
TRIM2 tripartite motif containing 2
UBXN4 UBX domain protein 4
UGDH UDP-glucose 6-dehydrogenase
WIF1 WNT inhibitory factor 1
ZC3H15 zinc finger CCCH-type containing 15

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADGRE5 adhesion G protein-coupled receptor E5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AGTR1 angiotensin II receptor, type 1
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
ARHGAP29 Rho GTPase activating protein 29
ASPH aspartate beta-hydroxylase
B3GNT1
BIK BCL2-interacting killer (apoptosis-inducing)
BTBD3 BTB (POZ) domain containing 3
C11ORF48
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCND1 cyclin D1
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CLIC3 chloride intracellular channel 3
COG2 component of oligomeric golgi complex 2
CTBP2 C-terminal binding protein 2
DES desmin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUOX2 dual oxidase 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
E2F5 E2F transcription factor 5, p130-binding
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FLRT2 fibronectin leucine rich transmembrane protein 2
FST follistatin
G0S2 G0/G1 switch 2
GSTM3 glutathione S-transferase mu 3 (brain)
HOXA10 homeobox A10
HOXA5 homeobox A5
IGFBP3 insulin-like growth factor binding protein 3
IRS1 insulin receptor substrate 1
KRT18 keratin 18, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MGLL monoglyceride lipase
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MXRA7 matrix-remodelling associated 7
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYH11 myosin, heavy chain 11, smooth muscle
MYOF myoferlin
NFIB nuclear factor I/B
NT5E 5'-nucleotidase, ecto (CD73)
PBX3 pre-B-cell leukemia homeobox 3
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G16 phospholipase A2, group XVI
PODXL podocalyxin-like
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSRC1 proline/serine-rich coiled-coil 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCAND1 SCAN domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TACSTD2 tumor-associated calcium signal transducer 2
TCEAL4 transcription elongation factor A (SII)-like 4
TFF1 trefoil factor 1
TMEM251 transmembrane protein 251
TPM1 tropomyosin 1 (alpha)
TRIM44 tripartite motif containing 44
VEGFC vascular endothelial growth factor C
WFDC1 WAP four-disulfide core domain 1
ZBED2 zinc finger, BED-type containing 2
ZBED5 zinc finger, BED-type containing 5
ZNF185 zinc finger protein 185 (LIM domain)
ZSCAN18 zinc finger and SCAN domain containing 18
Funding