BRD-K88510285_B675700.cdx_RMGI_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K88510285_B675700.cdx_RMGI_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABHD4 abhydrolase domain containing 4
ABHD6 abhydrolase domain containing 6
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BACE2 beta-site APP-cleaving enzyme 2
BAG3 BCL2-associated athanogene 3
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CGRRF1 cell growth regulator with ring finger domain 1
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)
CLEC2B C-type lectin domain family 2, member B
CLIC5 chloride intracellular channel 5
CSRP1 cysteine and glycine-rich protein 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5R1 cytochrome b5 reductase 1
CYBB cytochrome b-245, beta polypeptide
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
E2F2 E2F transcription factor 2
EFNB2 ephrin-B2
FASTKD5 FAST kinase domains 5
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS1 growth arrest-specific 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
IL1R2 interleukin 1 receptor, type II
IPO13 importin 13
KCTD12 potassium channel tetramerization domain containing 12
KDM5A lysine (K)-specific demethylase 5A
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LIMS1 LIM and senescent cell antigen-like domains 1
MAOB monoamine oxidase B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP1 matrix metallopeptidase 1
MSRB2 methionine sulfoxide reductase B2
MYBPC1 myosin binding protein C, slow type
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDE4DIP phosphodiesterase 4D interacting protein
PKP1 plakophilin 1
PMEPA1 prostate transmembrane protein, androgen induced 1
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PRSS21 protease, serine, 21 (testisin)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIK1 salt-inducible kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR1B small proline-rich protein 1B
SSPN sarcospan
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TBP TATA box binding protein
TLR4 toll-like receptor 4
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
TWIST1 twist family bHLH transcription factor 1

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADIRF adipogenesis regulatory factor
AGRN agrin
AKAP12 A kinase (PRKA) anchor protein 12
ANXA4 annexin A4
AOX1 aldehyde oxidase 1
AUTS2 autism susceptibility candidate 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CENPA centromere protein A
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CNPY3 canopy FGF signaling regulator 3
CRIP2 cysteine-rich protein 2
CTSC cathepsin C
CXCL12 chemokine (C-X-C motif) ligand 12
DDAH1 dimethylarginine dimethylaminohydrolase 1
DLK1 delta-like 1 homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENO1 enolase 1, (alpha)
ERBB3 erb-b2 receptor tyrosine kinase 3
F11R F11 receptor
FAM13A family with sequence similarity 13, member A
FBXO11 F-box protein 11
FGB fibrinogen beta chain
GATA3 GATA binding protein 3
GPM6B glycoprotein M6B
HILPDA hypoxia inducible lipid droplet-associated
IGFBP4 insulin-like growth factor binding protein 4
INA internexin neuronal intermediate filament protein, alpha
LITAF lipopolysaccharide-induced TNF factor
LMNA lamin A/C
MARCKS myristoylated alanine-rich protein kinase C substrate
MGLL monoglyceride lipase
MUC1 mucin 1, cell surface associated
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
PBX3 pre-B-cell leukemia homeobox 3
PEG10 paternally expressed 10
PON2 paraoxonase 2
RBP4 retinol binding protein 4, plasma
RBPMS RNA binding protein with multiple splicing
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SEPT9 septin 9
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
STS steroid sulfatase (microsomal), isozyme S
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNIP1 TNFAIP3 interacting protein 1
TOX3 TOX high mobility group box family member 3
TRIM14 tripartite motif containing 14
UBE2C ubiquitin-conjugating enzyme E2C
UGP2 UDP-glucose pyrophosphorylase 2
VAMP8 vesicle-associated membrane protein 8
VCAN versican
Funding