BRD-K88510285_B675700.cdx_SNGM_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K88510285_B675700.cdx_SNGM_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CEMIP cell migration inducing protein, hyaluronan binding
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CPD carboxypeptidase D
DEFA4 defensin, alpha 4, corticostatin
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELANE elastase, neutrophil expressed
FSD1 fibronectin type III and SPRY domain containing 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPO myeloperoxidase
MRPL18 mitochondrial ribosomal protein L18
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
ODC1 ornithine decarboxylase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SC5D sterol-C5-desaturase
SCYL2 SCY1-like 2 (S. cerevisiae)
SFRP4 secreted frizzled-related protein 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOCS2 suppressor of cytokine signaling 2
STK17B serine/threonine kinase 17b
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMSB15A thymosin beta 15a
TRIB3 tribbles pseudokinase 3
UFD1L ubiquitin fusion degradation 1 like (yeast)
ZFR zinc finger RNA binding protein

decreased expression

Symbol Name
ACLY ATP citrate lyase
AK4 adenylate kinase 4
ARL4C ADP-ribosylation factor-like 4C
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
C1ORF106 chromosome 1 open reading frame 106
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND1 cyclin D1
CCNF cyclin F
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHI3L2 chitinase 3-like 2
CST1 cystatin SN
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
CYBA cytochrome b-245, alpha polypeptide
ENO2 enolase 2 (gamma, neuronal)
EPCAM epithelial cell adhesion molecule
ETV1 ets variant 1
ETV5 ets variant 5
FMO2 flavin containing monooxygenase 2 (non-functional)
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
HILPDA hypoxia inducible lipid droplet-associated
HMGA2 high mobility group AT-hook 2
HN1 hematological and neurological expressed 1
HOXA5 homeobox A5
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IGHM immunoglobulin heavy constant mu
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ISG15 ISG15 ubiquitin-like modifier
KRT19 keratin 19, type I
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LXN latexin
LYN LYN proto-oncogene, Src family tyrosine kinase
LYPLA1 lysophospholipase I
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
MGLL monoglyceride lipase
MGP matrix Gla protein
MMD monocyte to macrophage differentiation-associated
MX1 MX dynamin-like GTPase 1
NEBL nebulette
NFIB nuclear factor I/B
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PEBP1 phosphatidylethanolamine binding protein 1
PFKP phosphofructokinase, platelet
PLA2G16 phospholipase A2, group XVI
PLAGL1 pleiomorphic adenoma gene-like 1
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNMA2 paraneoplastic Ma antigen 2
PODXL podocalyxin-like
PROM1 prominin 1
PRSS2 protease, serine, 2 (trypsin 2)
RBM34 RNA binding motif protein 34
RBM47 RNA binding motif protein 47
RBPMS RNA binding protein with multiple splicing
RHOBTB3 Rho-related BTB domain containing 3
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
RRAGD Ras-related GTP binding D
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP1 secreted frizzled-related protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPTBN1 spectrin, beta, non-erythrocytic 1
TAPBP TAP binding protein (tapasin)
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TSNAX translin-associated factor X
TSPAN3 tetraspanin 3
TUBA1A tubulin, alpha 1a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
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