BRD-K88510285_B675700.cdx_THP1_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

201 genes differentially expressed following the BRD-K88510285_B675700.cdx_THP1_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCAM basal cell adhesion molecule (Lutheran blood group)
BTG3 BTG family, member 3
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD99 CD99 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGA chromogranin A
CHGB chromogranin B
CLDN10 claudin 10
CLEC2B C-type lectin domain family 2, member B
CLEC3B C-type lectin domain family 3, member B
CLIC4 chloride intracellular channel 4
CLU clusterin
COL6A2 collagen, type VI, alpha 2
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DPP4 dipeptidyl-peptidase 4
DUSP1 dual specificity phosphatase 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EML1 echinoderm microtubule associated protein like 1
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FASN fatty acid synthase
FOSL1 FOS-like antigen 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GJA1 gap junction protein, alpha 1, 43kDa
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
INSM1 insulinoma-associated 1
IPO13 importin 13
JUN jun proto-oncogene
LOC100505650 uncharacterized LOC100505650
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MPZL2 myelin protein zero-like 2
MSMO1 methylsterol monooxygenase 1
MT1G metallothionein 1G
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NQO2 NAD(P)H dehydrogenase, quinone 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAGE4 P antigen family, member 4 (prostate associated)
PCSK1 proprotein convertase subtilisin/kexin type 1
PERP PERP, TP53 apoptosis effector
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTPRO protein tyrosine phosphatase, receptor type, O
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SNAP25 synaptosomal-associated protein, 25kDa
SST somatostatin
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TDP2 tyrosyl-DNA phosphodiesterase 2
TES testin LIM domain protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM41B transmembrane protein 41B
TNNT1 troponin T type 1 (skeletal, slow)
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
UBXN4 UBX domain protein 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFD1L ubiquitin fusion degradation 1 like (yeast)
WBP5 WW domain binding protein 5
WIF1 WNT inhibitory factor 1
ZIC1 Zic family member 1

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACTN1 actinin, alpha 1
ADGRE5 adhesion G protein-coupled receptor E5
AKAP12 A kinase (PRKA) anchor protein 12
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKRD10 ankyrin repeat domain 10
ANXA3 annexin A3
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
AZU1 azurocidin 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL2 B-cell CLL/lymphoma 2
BIK BCL2-interacting killer (apoptosis-inducing)
C7 complement component 7
CA2 carbonic anhydrase II
CCND3 cyclin D3
CLEC11A C-type lectin domain family 11, member A
CLMN calmin (calponin-like, transmembrane)
CPVL carboxypeptidase, vitellogenic-like
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSK c-src tyrosine kinase
CSTA cystatin A (stefin A)
CTSG cathepsin G
CTSS cathepsin S
CXCR4 chemokine (C-X-C motif) receptor 4
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
DUSP6 dual specificity phosphatase 6
FAM216A family with sequence similarity 216, member A
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GALE UDP-galactose-4-epimerase
GAS1 growth arrest-specific 1
GPX1 glutathione peroxidase 1
GPX2 glutathione peroxidase 2
HOXA10 homeobox A10
IGHM immunoglobulin heavy constant mu
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KCTD12 potassium channel tetramerization domain containing 12
KLF4 Kruppel-like factor 4 (gut)
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPL lipoprotein lipase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTSS1 metastasis suppressor 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NREP neuronal regeneration related protein
PBX3 pre-B-cell leukemia homeobox 3
PCYOX1L prenylcysteine oxidase 1 like
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
PLEK pleckstrin
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSRC1 proline/serine-rich coiled-coil 1
PTK2B protein tyrosine kinase 2 beta
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RFX5 regulatory factor X, 5 (influences HLA class II expression)
S100A9 S100 calcium binding protein A9
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SMAD3 SMAD family member 3
SMCO4 single-pass membrane protein with coiled-coil domains 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TCL1A T-cell leukemia/lymphoma 1A
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM5 transmembrane protein 5
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNS3 tensin 3
TRIB2 tribbles pseudokinase 2
TRIM13 tripartite motif containing 13
TRIM14 tripartite motif containing 14
UBL3 ubiquitin-like 3
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