BRD-K88510285_B675700.cdx_WSUDLCL2_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-K88510285_B675700.cdx_WSUDLCL2_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADGRG6 adhesion G protein-coupled receptor G6
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANGPT1 angiopoietin 1
ANXA1 annexin A1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BAG3 BCL2-associated athanogene 3
CALR calreticulin
CD163 CD163 molecule
CD300A CD300a molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD69 CD69 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA4 chloride channel accessory 4
CLEC2B C-type lectin domain family 2, member B
CNN3 calponin 3, acidic
COL1A2 collagen, type I, alpha 2
CSRP2 cysteine and glycine-rich protein 2
CTH cystathionine gamma-lyase
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM129A family with sequence similarity 129, member A
FGFR1 fibroblast growth factor receptor 1
FN1 fibronectin 1
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSDMB gasdermin B
HAPLN1 hyaluronan and proteoglycan link protein 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOPX HOP homeobox
HPSE heparanase
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KRT13 keratin 13, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT4 keratin 4, type II
KRT8 keratin 8, type II
LCN2 lipocalin 2
LPAR6 lysophosphatidic acid receptor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGP matrix Gla protein
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MTUS1 microtubule associated tumor suppressor 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A14 S100 calcium binding protein A14
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
SRGN serglycin
TBC1D31 TBC1 domain family, member 31
TGFBI transforming growth factor, beta-induced, 68kDa
TIAM1 T-cell lymphoma invasion and metastasis 1
TPD52L1 tumor protein D52-like 1
TRD T cell receptor delta locus
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UFD1L ubiquitin fusion degradation 1 like (yeast)
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4

decreased expression

Symbol Name
ANXA6 annexin A6
ATPIF1 ATPase inhibitory factor 1
AZU1 azurocidin 1
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BIK BCL2-interacting killer (apoptosis-inducing)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CD24 CD24 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CDC42 cell division cycle 42
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHSY1 chondroitin sulfate synthase 1
CKB creatine kinase, brain
CRIP1 cysteine-rich protein 1 (intestinal)
CSK c-src tyrosine kinase
CTSG cathepsin G
CXCL14 chemokine (C-X-C motif) ligand 14
CYFIP2 cytoplasmic FMR1 interacting protein 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP7 dual specificity phosphatase 7
ELF5 E74-like factor 5 (ets domain transcription factor)
FAM3C family with sequence similarity 3, member C
FKBP11 FK506 binding protein 11, 19 kDa
FTO fat mass and obesity associated
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GAS1 growth arrest-specific 1
GNAS GNAS complex locus
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HIST1H2BK histone cluster 1, H2bk
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
ISG15 ISG15 ubiquitin-like modifier
JADE2 jade family PHD finger 2
KLF4 Kruppel-like factor 4 (gut)
LUM lumican
MARCKS myristoylated alanine-rich protein kinase C substrate
MRPL20 mitochondrial ribosomal protein L20
MXRA7 matrix-remodelling associated 7
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
NFIB nuclear factor I/B
NREP neuronal regeneration related protein
PAX5 paired box 5
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POU2AF1 POU class 2 associating factor 1
PRDX2 peroxiredoxin 2
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PTGES prostaglandin E synthase
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PURA purine-rich element binding protein A
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC35E2B solute carrier family 35, member E2B
SORD sorbitol dehydrogenase
STXBP2 syntaxin binding protein 2
TCL1A T-cell leukemia/lymphoma 1A
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR3 transforming growth factor, beta receptor III
TLR4 toll-like receptor 4
TPD52 tumor protein D52
TRAC T cell receptor alpha constant
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VPREB3 pre-B lymphocyte 3
Funding