BRD-K88573743_A443654_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

209 genes differentially expressed following the BRD-K88573743_A443654_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSS3 acyl-CoA synthetase short-chain family member 3
ADGRL3 adhesion G protein-coupled receptor L3
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHNAK2 AHNAK nucleoprotein 2
AKAP8L A kinase (PRKA) anchor protein 8-like
ALB albumin
ANKRD10 ankyrin repeat domain 10
ANOS1 anosmin 1
ANPEP alanyl (membrane) aminopeptidase
ASPN asporin
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BMP2 bone morphogenetic protein 2
C5AR1 complement component 5a receptor 1
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CD83 CD83 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHL1 cell adhesion molecule L1-like
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC7A C-type lectin domain family 7, member A
COL11A1 collagen, type XI, alpha 1
COL21A1 collagen, type XXI, alpha 1
CPD carboxypeptidase D
CPE carboxypeptidase E
CRYAB crystallin, alpha B
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDR1 discoidin domain receptor tyrosine kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DMXL2 Dmx-like 2
DOK5 docking protein 5
DUSP2 dual specificity phosphatase 2
ECHDC2 enoyl CoA hydratase domain containing 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELL2 elongation factor, RNA polymerase II, 2
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
FAM8A1 family with sequence similarity 8, member A1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FRY furry homolog (Drosophila)
FST follistatin
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLUL glutamate-ammonia ligase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOMER1 homer scaffolding protein 1
HOPX HOP homeobox
HP haptoglobin
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IL2RG interleukin 2 receptor, gamma
IL6R interleukin 6 receptor
ITGAV integrin, alpha V
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LHX2 LIM homeobox 2
LRRC15 leucine rich repeat containing 15
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP2 microtubule-associated protein 2
MBD4 methyl-CpG binding domain protein 4
MCL1 myeloid cell leukemia 1
MDFIC MyoD family inhibitor domain containing
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
NCK1 NCK adaptor protein 1
NDFIP1 Nedd4 family interacting protein 1
PDZD2 PDZ domain containing 2
PEG3 paternally expressed 3
PLN phospholamban
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP4 retinol binding protein 4, plasma
RGS2 regulator of G-protein signaling 2
RORA RAR-related orphan receptor A
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
SAMD4A sterile alpha motif domain containing 4A
SATB2 SATB homeobox 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SRPR signal recognition particle receptor (docking protein)
SST somatostatin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STK38L serine/threonine kinase 38 like
SULF1 sulfatase 1
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM259 transmembrane protein 259
TNIK TRAF2 and NCK interacting kinase
TOR1A torsin family 1, member A (torsin A)
TYROBP TYRO protein tyrosine kinase binding protein
VNN1 vanin 1
WT1 Wilms tumor 1

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
APOD apolipoprotein D
ARHGAP29 Rho GTPase activating protein 29
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATG3 autophagy related 3
ATMIN ATM interactor
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BASP1 brain abundant, membrane attached signal protein 1
BICC1 BicC family RNA binding protein 1
BST2 bone marrow stromal cell antigen 2
CA2 carbonic anhydrase II
CCND1 cyclin D1
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLTA clathrin, light chain A
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FGFR2 fibroblast growth factor receptor 2
FHL2 four and a half LIM domains 2
FKBP4 FK506 binding protein 4, 59kDa
FMO1 flavin containing monooxygenase 1
FSTL1 follistatin-like 1
FZD7 frizzled class receptor 7
G6PD glucose-6-phosphate dehydrogenase
GDF15 growth differentiation factor 15
GLOD4 glyoxalase domain containing 4
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX2 glutathione peroxidase 2
HBB hemoglobin, beta
HOXB7 homeobox B7
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
JCHAIN joining chain of multimeric IgA and IgM
KAZN kazrin, periplakin interacting protein
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LAP3 leucine aminopeptidase 3
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
MALL mal, T-cell differentiation protein-like
MALT1 MALT1 paracaspase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP7 matrix metallopeptidase 7
NMI N-myc (and STAT) interactor
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
OLFM4 olfactomedin 4
PCNA proliferating cell nuclear antigen
PFDN2 prefoldin subunit 2
PLCB4 phospholipase C, beta 4
PNP purine nucleoside phosphorylase
PROM1 prominin 1
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPRK protein tyrosine phosphatase, receptor type, K
RAE1 ribonucleic acid export 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS11 ribosomal protein S11
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SCGB1D2 secretoglobin, family 1D, member 2
SLPI secretory leukocyte peptidase inhibitor
SOX9 SRY (sex determining region Y)-box 9
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TPD52L1 tumor protein D52-like 1
TPM1 tropomyosin 1 (alpha)
TXNRD1 thioredoxin reductase 1
UBE2C ubiquitin-conjugating enzyme E2C
VCP valosin containing protein
XIST X inactive specific transcript (non-protein coding)
Funding