BRD-K88573743_A443654_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

203 genes differentially expressed following the BRD-K88573743_A443654_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
ANKRD36B ankyrin repeat domain 36B
BCL6 B-cell CLL/lymphoma 6
C19ORF54 chromosome 19 open reading frame 54
CA2 carbonic anhydrase II
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHGB chromogranin B
COASY CoA synthase
CPT1A carnitine palmitoyltransferase 1A (liver)
CTBP1 C-terminal binding protein 1
CXADR coxsackie virus and adenovirus receptor
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DUSP6 dual specificity phosphatase 6
FBN2 fibrillin 2
FOXG1 forkhead box G1
GSDMB gasdermin B
HDAC6 histone deacetylase 6
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INSM1 insulinoma-associated 1
IVNS1ABP influenza virus NS1A binding protein
LINC00342 long intergenic non-protein coding RNA 342
LOC100272216 uncharacterized LOC100272216
LONP2 lon peptidase 2, peroxisomal
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MCF2L MCF.2 cell line derived transforming sequence-like
MLPH melanophilin
NBPF10 neuroblastoma breakpoint family, member 10
NELL2 NEL-like 2 (chicken)
NKTR natural killer cell triggering receptor
NR4A2 nuclear receptor subfamily 4, group A, member 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBLD phenazine biosynthesis-like protein domain containing
PILRB paired immunoglobin-like type 2 receptor beta
PROM1 prominin 1
PTCH1 patched 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBL2 retinoblastoma-like 2
RBM8A RNA binding motif protein 8A
REC8 REC8 meiotic recombination protein
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNF167 ring finger protein 167
RSRP1 arginine/serine-rich protein 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC35E2B solute carrier family 35, member E2B
SOX4 SRY (sex determining region Y)-box 4
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
TARDBP TAR DNA binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TOB1 transducer of ERBB2, 1
TSTA3 tissue specific transplantation antigen P35B
TXNIP thioredoxin interacting protein
USP34 ubiquitin specific peptidase 34
VNN1 vanin 1

decreased expression

Symbol Name
ADAM19 ADAM metallopeptidase domain 19
ADK adenosine kinase
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
APOA2 apolipoprotein A-II
APOD apolipoprotein D
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C3 complement component 3
CALU calumenin
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CD9 CD9 molecule
CFH complement factor H
CFLAR CASP8 and FADD-like apoptosis regulator
CKB creatine kinase, brain
CLIC3 chloride intracellular channel 3
COL14A1 collagen, type XIV, alpha 1
COL16A1 collagen, type XVI, alpha 1
COL5A1 collagen, type V, alpha 1
COL9A3 collagen, type IX, alpha 3
COMMD10 COMM domain containing 10
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
EGF epidermal growth factor
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
ERAP2 endoplasmic reticulum aminopeptidase 2
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FAM162A family with sequence similarity 162, member A
FBN1 fibrillin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GDF15 growth differentiation factor 15
GPRC5A G protein-coupled receptor, class C, group 5, member A
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HILPDA hypoxia inducible lipid droplet-associated
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIAA0226L KIAA0226-like
LDLR low density lipoprotein receptor
LITAF lipopolysaccharide-induced TNF factor
LOXL1 lysyl oxidase-like 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP4 microfibrillar-associated protein 4
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NREP neuronal regeneration related protein
OLFM4 olfactomedin 4
OLFML3 olfactomedin-like 3
ORM1 orosomucoid 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCCB propionyl CoA carboxylase, beta polypeptide
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PDGFA platelet-derived growth factor alpha polypeptide
PDIA5 protein disulfide isomerase family A, member 5
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIR pirin (iron-binding nuclear protein)
PITX1 paired-like homeodomain 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRSS21 protease, serine, 21 (testisin)
PTGDS prostaglandin D2 synthase 21kDa (brain)
QPRT quinolinate phosphoribosyltransferase
RAB32 RAB32, member RAS oncogene family
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
REEP5 receptor accessory protein 5
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SC5D sterol-C5-desaturase
SDC2 syndecan 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SGCE sarcoglycan, epsilon
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNRPE small nuclear ribonucleoprotein polypeptide E
SPATS2L spermatogenesis associated, serine-rich 2-like
SQLE squalene epoxidase
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TCL1A T-cell leukemia/lymphoma 1A
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNIP1 TNFAIP3 interacting protein 1
TRBC1 T cell receptor beta constant 1
TRIB3 tribbles pseudokinase 3
TUBB2A tubulin, beta 2A class IIa
VSNL1 visinin-like 1
WNT5A wingless-type MMTV integration site family, member 5A
ZNF185 zinc finger protein 185 (LIM domain)
Funding