BRD-K88573743_A443654_HS578T_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K88573743_A443654_HS578T_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ANKRD10 ankyrin repeat domain 10
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPN asporin
BCHE butyrylcholinesterase
BEX1 brain expressed, X-linked 1
BLNK B-cell linker
CES1 carboxylesterase 1
CHRDL1 chordin-like 1
CXCL5 chemokine (C-X-C motif) ligand 5
DES desmin
EIF5A eukaryotic translation initiation factor 5A
FAM3C family with sequence similarity 3, member C
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FOLR1 folate receptor 1 (adult)
GMDS GDP-mannose 4,6-dehydratase
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPM6A glycoprotein M6A
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
LAPTM5 lysosomal protein transmembrane 5
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR2 lysophosphatidic acid receptor 2
LTBP3 latent transforming growth factor beta binding protein 3
MAGED1 melanoma antigen family D1
MAOA monoamine oxidase A
MEF2C myocyte enhancer factor 2C
MGP matrix Gla protein
MYO6 myosin VI
NGRN neugrin, neurite outgrowth associated
PCP4 Purkinje cell protein 4
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLD3 phospholipase D family, member 3
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
PTPRD protein tyrosine phosphatase, receptor type, D
RPL31 ribosomal protein L31
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFTPB surfactant protein B
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPP1 secreted phosphoprotein 1
TFPI2 tissue factor pathway inhibitor 2
THBS4 thrombospondin 4
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN12 tetraspanin 12
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
WWTR1 WW domain containing transcription regulator 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADM adrenomedullin
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4C ADP-ribosylation factor-like 4C
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
AURKA aurora kinase A
AXIN1 axin 1
BAMBI BMP and activin membrane-bound inhibitor
BCL10 B-cell CLL/lymphoma 10
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CALML3 calmodulin-like 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBR3 carbonyl reductase 3
CCDC59 coiled-coil domain containing 59
CCNE2 cyclin E2
CCR7 chemokine (C-C motif) receptor 7
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COIL coilin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR2 early growth response 2
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
FBXL14 F-box and leucine-rich repeat protein 14
FKBP4 FK506 binding protein 4, 59kDa
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIC2 hypermethylated in cancer 2
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGKV4-1 immunoglobulin kappa variable 4-1
IL7R interleukin 7 receptor
INSIG1 insulin induced gene 1
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JUN jun proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM5D lysine (K)-specific demethylase 5D
KIAA0355 KIAA0355
KLF10 Kruppel-like factor 10
KLF11 Kruppel-like factor 11
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KRT6B keratin 6B, type II
LAMA3 laminin, alpha 3
LEF1 lymphoid enhancer-binding factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MTERF3 mitochondrial transcription termination factor 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
PELO pelota homolog (Drosophila)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAGL2 pleiomorphic adenoma gene-like 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
RCAN1 regulator of calcineurin 1
RHOB ras homolog family member B
SAP30 Sin3A-associated protein, 30kDa
SCML1 sex comb on midleg-like 1 (Drosophila)
SERTAD2 SERTA domain containing 2
SGK1 serum/glucocorticoid regulated kinase 1
SIRT3 sirtuin 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A2 solute carrier family 38, member 2
SMAGP small cell adhesion glycoprotein
SNRK SNF related kinase
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TBP TATA box binding protein
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGIF1 TGFB-induced factor homeobox 1
TOB2 transducer of ERBB2, 2
TRBC1 T cell receptor beta constant 1
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF200 zinc finger protein 200
Funding