BRD-K88573743_A443654_HS578T_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-K88573743_A443654_HS578T_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA1 acetyl-CoA acyltransferase 1
ALCAM activated leukocyte cell adhesion molecule
ALOX5 arachidonate 5-lipoxygenase
ANKRD10 ankyrin repeat domain 10
APOC1 apolipoprotein C-I
ARL3 ADP-ribosylation factor-like 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BCHE butyrylcholinesterase
C7 complement component 7
CAV2 caveolin 2
CERS6 ceramide synthase 6
CFH complement factor H
CHMP4A charged multivesicular body protein 4A
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CPVL carboxypeptidase, vitellogenic-like
CTSH cathepsin H
CXCL5 chemokine (C-X-C motif) ligand 5
CYFIP2 cytoplasmic FMR1 interacting protein 2
EIF5A eukaryotic translation initiation factor 5A
FKBP14 FK506 binding protein 14, 22 kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
FNBP1 formin binding protein 1
GLG1 golgi glycoprotein 1
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITGAV integrin, alpha V
LPL lipoprotein lipase
LTBP3 latent transforming growth factor beta binding protein 3
MMP9 matrix metallopeptidase 9
MT1M metallothionein 1M
MXRA5 matrix-remodelling associated 5
MYO6 myosin VI
NBL1 neuroblastoma 1, DAN family BMP antagonist
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PILRB paired immunoglobin-like type 2 receptor beta
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGES prostaglandin E synthase
SEPW1 selenoprotein W, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORD sorbitol dehydrogenase
SPAG4 sperm associated antigen 4
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53TG1 TP53 target 1 (non-protein coding)
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN13 tetraspanin 13
TTC3 tetratricopeptide repeat domain 3
TUBB6 tubulin, beta 6 class V

decreased expression

Symbol Name
ADM adrenomedullin
AQP3 aquaporin 3 (Gill blood group)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4C ADP-ribosylation factor-like 4C
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
AURKA aurora kinase A
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAMBI BMP and activin membrane-bound inhibitor
BCL10 B-cell CLL/lymphoma 10
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C1ORF106 chromosome 1 open reading frame 106
CA1 carbonic anhydrase I
CBR3 carbonyl reductase 3
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
EMX2 empty spiracles homeobox 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FBXL14 F-box and leucine-rich repeat protein 14
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
INSIG1 insulin induced gene 1
IVNS1ABP influenza virus NS1A binding protein
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL9 kelch-like family member 9
KRT5 keratin 5, type II
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRN1 neuritin 1
PDGFA platelet-derived growth factor alpha polypeptide
PELO pelota homolog (Drosophila)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTRH2 peptidyl-tRNA hydrolase 2
PTX3 pentraxin 3, long
RAE1 ribonucleic acid export 1
RAP2B RAP2B, member of RAS oncogene family
RFTN1 raftlin, lipid raft linker 1
RGS4 regulator of G-protein signaling 4
RND3 Rho family GTPase 3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCAF8 SR-related CTD-associated factor 8
SERTAD2 SERTA domain containing 2
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SMAGP small cell adhesion glycoprotein
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
STC1 stanniocalcin 1
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSC22D2 TSC22 domain family, member 2
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUFT1 tuftelin 1
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
Funding