BRD-K88573743_A443654_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K88573743_A443654_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKRD10 ankyrin repeat domain 10
CD52 CD52 molecule
CLEC11A C-type lectin domain family 11, member A
COL6A3 collagen, type VI, alpha 3
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
FABP4 fatty acid binding protein 4, adipocyte
GOLGA8A golgin A8 family, member A
GPX1 glutathione peroxidase 1
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
KIAA1033 KIAA1033
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MME membrane metallo-endopeptidase
MSN moesin
MXRA5 matrix-remodelling associated 5
NARFL nuclear prelamin A recognition factor-like
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NKTR natural killer cell triggering receptor
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NTS neurotensin
PHYH phytanoyl-CoA 2-hydroxylase
PLBD1 phospholipase B domain containing 1
PLIN3 perilipin 3
PTPRE protein tyrosine phosphatase, receptor type, E
PXDN peroxidasin
QPCT glutaminyl-peptide cyclotransferase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RNF130 ring finger protein 130
SKAP2 src kinase associated phosphoprotein 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TRA2A transformer 2 alpha homolog (Drosophila)
TRAF5 TNF receptor-associated factor 5
VIM vimentin
ZDHHC6 zinc finger, DHHC-type containing 6
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AHR aryl hydrocarbon receptor
ANXA3 annexin A3
ASF1A anti-silencing function 1A histone chaperone
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BCL7B B-cell CLL/lymphoma 7B
BIRC3 baculoviral IAP repeat containing 3
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLEC3B C-type lectin domain family 3, member B
CLU clusterin
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP14 dual specificity phosphatase 14
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FASTKD5 FAST kinase domains 5
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
KLHL9 kelch-like family member 9
KLK5 kallikrein-related peptidase 5
KRT23 keratin 23, type I
MAT2A methionine adenosyltransferase II, alpha
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PROM1 prominin 1
RAE1 ribonucleic acid export 1
RPS11 ribosomal protein S11
SCGB2A2 secretoglobin, family 2A, member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SOX9 SRY (sex determining region Y)-box 9
TBP TATA box binding protein
TBPL1 TBP-like 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TUFT1 tuftelin 1
USP1 ubiquitin specific peptidase 1
VEZF1 vascular endothelial zinc finger 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF22 zinc finger protein 22
Funding