BRD-K88625236_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K88625236_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACTA1 actin, alpha 1, skeletal muscle
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
CA2 carbonic anhydrase II
CD52 CD52 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CRABP1 cellular retinoic acid binding protein 1
CTGF connective tissue growth factor
DDIT4 DNA-damage-inducible transcript 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOCK4 dedicator of cytokinesis 4
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM69A family with sequence similarity 69, member A
FRZB frizzled-related protein
GUSBP11 glucuronidase, beta pseudogene 11
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
MAP7 microtubule-associated protein 7
MT1F metallothionein 1F
MTERF3 mitochondrial transcription termination factor 3
NDRG1 N-myc downstream regulated 1
NEB nebulin
NEFL neurofilament, light polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRUNE2 prune homolog 2 (Drosophila)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RFTN1 raftlin, lipid raft linker 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLN sarcolipin
STAB1 stabilin 1
STC2 stanniocalcin 2
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TPD52L1 tumor protein D52-like 1
TRAF5 TNF receptor-associated factor 5
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANXA1 annexin A1
ANXA3 annexin A3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BEX1 brain expressed, X-linked 1
CCNG1 cyclin G1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CLC Charcot-Leyden crystal galectin
CLEC11A C-type lectin domain family 11, member A
CPVL carboxypeptidase, vitellogenic-like
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DHCR24 24-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLG5 discs, large homolog 5 (Drosophila)
FAM57A family with sequence similarity 57, member A
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GATA3 GATA binding protein 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP4 insulin-like growth factor binding protein 4
IL6ST interleukin 6 signal transducer
IRS2 insulin receptor substrate 2
KRT4 keratin 4, type II
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
MNDA myeloid cell nuclear differentiation antigen
NQO1 NAD(P)H dehydrogenase, quinone 1
PTGES prostaglandin E synthase
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
S100A9 S100 calcium binding protein A9
SAR1A secretion associated, Ras related GTPase 1A
SELL selectin L
SGPL1 sphingosine-1-phosphate lyase 1
SORD sorbitol dehydrogenase
TBC1D4 TBC1 domain family, member 4
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
TKT transketolase
TM9SF3 transmembrane 9 superfamily member 3
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
ZBTB18 zinc finger and BTB domain containing 18