BRD-K89224880_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K89224880_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CTSL cathepsin L
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSG2 desmoglein 2
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
FHL2 four and a half LIM domains 2
FTH1 ferritin, heavy polypeptide 1
GSE1 Gse1 coiled-coil protein
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
KIF14 kinesin family member 14
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MMP1 matrix metallopeptidase 1
NCOA3 nuclear receptor coactivator 3
NRIP1 nuclear receptor interacting protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PTER phosphotriesterase related
RBKS ribokinase
RNMT RNA (guanine-7-) methyltransferase
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERTAD2 SERTA domain containing 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD24 CD24 molecule
CD8A CD8a molecule
CST7 cystatin F (leukocystatin)
FGFR3 fibroblast growth factor receptor 3
GBP1 guanylate binding protein 1, interferon-inducible
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMK granzyme K (granzyme 3; tryptase II)
IER3 immediate early response 3
IFI44 interferon-induced protein 44
IGFBP3 insulin-like growth factor binding protein 3
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KRT13 keratin 13, type I
KRT7 keratin 7, type II
NKG7 natural killer cell granule protein 7
PLN phospholamban
PPARG peroxisome proliferator-activated receptor gamma
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RPP25 ribonuclease P/MRP 25kDa subunit
STOM stomatin
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TUBB6 tubulin, beta 6 class V