BRD-K89224880_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K89224880_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
ACTN1 actinin, alpha 1
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BIN1 bridging integrator 1
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
CBR3 carbonyl reductase 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CRYAB crystallin, alpha B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FLNA filamin A, alpha
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GARS glycyl-tRNA synthetase
GATA6 GATA binding protein 6
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GSTA4 glutathione S-transferase alpha 4
HCAR3 hydroxycarboxylic acid receptor 3
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KLF10 Kruppel-like factor 10
MAP1B microtubule-associated protein 1B
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MMP7 matrix metallopeptidase 7
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NRCAM neuronal cell adhesion molecule
P3H2 prolyl 3-hydroxylase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCOLCE2 procollagen C-endopeptidase enhancer 2
PLCB4 phospholipase C, beta 4
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RHOB ras homolog family member B
RIOK3 RIO kinase 3
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS2 sorbin and SH3 domain containing 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STC2 stanniocalcin 2
TGFBI transforming growth factor, beta-induced, 68kDa
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
ADIRF adipogenesis regulatory factor
AIM1 absent in melanoma 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
C7 complement component 7
CA2 carbonic anhydrase II
CPE carboxypeptidase E
CXCL9 chemokine (C-X-C motif) ligand 9
DCN decorin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EPHA3 EPH receptor A3
ESR1 estrogen receptor 1
FILIP1L filamin A interacting protein 1-like
FUBP1 far upstream element (FUSE) binding protein 1
GBP1 guanylate binding protein 1, interferon-inducible
GOLT1B golgi transport 1B
HOXA5 homeobox A5
KIAA0907 KIAA0907
KRT7 keratin 7, type II
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MGP matrix Gla protein
MMP9 matrix metallopeptidase 9
MTUS1 microtubule associated tumor suppressor 1
MYH10 myosin, heavy chain 10, non-muscle
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OPHN1 oligophrenin 1
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
SCD5 stearoyl-CoA desaturase 5
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SKAP2 src kinase associated phosphoprotein 2
SOX4 SRY (sex determining region Y)-box 4
STMN1 stathmin 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFRC transferrin receptor
TGFB3 transforming growth factor, beta 3
TRIM22 tripartite motif containing 22
Funding