BRD-K89329876_-666_HA1E_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

190 genes differentially expressed following the BRD-K89329876_-666_HA1E_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C1QBP complement component 1, q subcomponent binding protein
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CD14 CD14 molecule
CD44 CD44 molecule (Indian blood group)
CDCP1 CUB domain containing protein 1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHGB chromogranin B
CLDN3 claudin 3
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DOCK4 dedicator of cytokinesis 4
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FCGBP Fc fragment of IgG binding protein
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GLRX glutaredoxin (thioltransferase)
GRB7 growth factor receptor-bound protein 7
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPH1 heat shock 105kDa/110kDa protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
IL1A interleukin 1, alpha
IPO13 importin 13
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
KLK10 kallikrein-related peptidase 10
KRT81 keratin 81, type II
LPAR6 lysophosphatidic acid receptor 6
MKNK1 MAP kinase interacting serine/threonine kinase 1
NELL2 NEL-like 2 (chicken)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NRCAM neuronal cell adhesion molecule
NT5E 5'-nucleotidase, ecto (CD73)
PCSK1 proprotein convertase subtilisin/kexin type 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PRNP prion protein
PSAT1 phosphoserine aminotransferase 1
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RTN1 reticulon 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SH2B3 SH2B adaptor protein 3
SHB Src homology 2 domain containing adaptor protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
STEAP3 STEAP family member 3, metalloreductase
STX1A syntaxin 1A (brain)
TARS threonyl-tRNA synthetase
TFPI2 tissue factor pathway inhibitor 2
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ABHD4 abhydrolase domain containing 4
ACAT2 acetyl-CoA acetyltransferase 2
ADAM12 ADAM metallopeptidase domain 12
ADD3 adducin 3 (gamma)
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
ANXA6 annexin A6
APOL1 apolipoprotein L, 1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BGN biglycan
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BST2 bone marrow stromal cell antigen 2
C9ORF3 chromosome 9 open reading frame 3
CBR3 carbonyl reductase 3
CCDC53 coiled-coil domain containing 53
CCL2 chemokine (C-C motif) ligand 2
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFI complement factor I
CFLAR CASP8 and FADD-like apoptosis regulator
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DCXR dicarbonyl/L-xylulose reductase
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGF epidermal growth factor
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FBN1 fibrillin 1
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GSTA4 glutathione S-transferase alpha 4
GSTM3 glutathione S-transferase mu 3 (brain)
HOXA10 homeobox A10
HOXA5 homeobox A5
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSDL2 hydroxysteroid dehydrogenase like 2
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IQGAP2 IQ motif containing GTPase activating protein 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
LBH limb bud and heart development
LIPA lipase A, lysosomal acid, cholesterol esterase
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
MAGED1 melanoma antigen family D1
MGP matrix Gla protein
MN1 meningioma (disrupted in balanced translocation) 1
MSMO1 methylsterol monooxygenase 1
MSRB2 methionine sulfoxide reductase B2
MYH10 myosin, heavy chain 10, non-muscle
MYLK myosin light chain kinase
NNMT nicotinamide N-methyltransferase
NREP neuronal regeneration related protein
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCP4 Purkinje cell protein 4
PCYOX1L prenylcysteine oxidase 1 like
PDLIM1 PDZ and LIM domain 1
PGM1 phosphoglucomutase 1
PLAC8 placenta-specific 8
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRCP prolylcarboxypeptidase (angiotensinase C)
PRSS23 protease, serine, 23
RCAN1 regulator of calcineurin 1
SCP2 sterol carrier protein 2
SEPT11 septin 11
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SIDT2 SID1 transmembrane family, member 2
SKAP2 src kinase associated phosphoprotein 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
SRP54 signal recognition particle 54kDa
SULF1 sulfatase 1
TMEM14A transmembrane protein 14A
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM1 tropomyosin 1 (alpha)
TSPAN6 tetraspanin 6
TSPAN8 tetraspanin 8
VCAM1 vascular cell adhesion molecule 1
WDTC1 WD and tetratricopeptide repeats 1
WNT5A wingless-type MMTV integration site family, member 5A
ZCCHC24 zinc finger, CCHC domain containing 24
ZMIZ1 zinc finger, MIZ-type containing 1
Funding