BRD-K89329876_-666_SW620_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K89329876_-666_SW620_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
ATF1 activating transcription factor 1
CD40 CD40 molecule, TNF receptor superfamily member 5
CFD complement factor D (adipsin)
COL10A1 collagen, type X, alpha 1
COMP cartilage oligomeric matrix protein
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYCS cytochrome c, somatic
DCN decorin
DLD dihydrolipoamide dehydrogenase
DOCK10 dedicator of cytokinesis 10
ERBB3 erb-b2 receptor tyrosine kinase 3
FYB FYN binding protein
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLS glutaminase
HDGFRP3 hepatoma-derived growth factor, related protein 3
HOXA10 homeobox A10
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
IL32 interleukin 32
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITK IL2-inducible T-cell kinase
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LTB lymphotoxin beta (TNF superfamily, member 3)
LUM lumican
MPZL1 myelin protein zero-like 1
OAT ornithine aminotransferase
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PRNP prion protein
PTGDS prostaglandin D2 synthase 21kDa (brain)
REEP5 receptor accessory protein 5
S100A13 S100 calcium binding protein A13
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
TLR4 toll-like receptor 4
TRIB1 tribbles pseudokinase 1
UBE3C ubiquitin protein ligase E3C
USP22 ubiquitin specific peptidase 22
ZEB2 zinc finger E-box binding homeobox 2

decreased expression

Symbol Name
AGR2 anterior gradient 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ARG1 arginase 1
ASCL1 achaete-scute family bHLH transcription factor 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
CALCA calcitonin-related polypeptide alpha
CXCL14 chemokine (C-X-C motif) ligand 14
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ESR1 estrogen receptor 1
HDAC9 histone deacetylase 9
HP haptoglobin
HSPB8 heat shock 22kDa protein 8
IGFBP3 insulin-like growth factor binding protein 3
IL1R2 interleukin 1 receptor, type II
KDM5D lysine (K)-specific demethylase 5D
LHX2 LIM homeobox 2
LOC100505650 uncharacterized LOC100505650
LRRC17 leucine rich repeat containing 17
MLEC malectin
NCAM1 neural cell adhesion molecule 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
ORM1 orosomucoid 1
PLK2 polo-like kinase 2
PRR7 proline rich 7 (synaptic)
RGS5 regulator of G-protein signaling 5
WFDC2 WAP four-disulfide core domain 2
Funding