BRD-K89451433_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

173 genes differentially expressed following the BRD-K89451433_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ANXA6 annexin A6
ARG2 arginase 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BLNK B-cell linker
C3ORF14 chromosome 3 open reading frame 14
CBR3 carbonyl reductase 3
CCND2 cyclin D2
CD200 CD200 molecule
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRDL1 chordin-like 1
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FAM13A family with sequence similarity 13, member A
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
FOXO4 forkhead box O4
FXYD5 FXYD domain containing ion transport regulator 5
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GULP1 GULP, engulfment adaptor PTB domain containing 1
GYPC glycophorin C (Gerbich blood group)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI44 interferon-induced protein 44
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1 insulin-like growth factor 1 (somatomedin C)
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
ITM2C integral membrane protein 2C
KCNK3 potassium channel, two pore domain subfamily K, member 3
KRT81 keratin 81, type II
LAPTM5 lysosomal protein transmembrane 5
LEF1 lymphoid enhancer-binding factor 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR6 lysophosphatidic acid receptor 6
LRRN3 leucine rich repeat neuronal 3
LXN latexin
MAN1A1 mannosidase, alpha, class 1A, member 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MOXD1 monooxygenase, DBH-like 1
MSMO1 methylsterol monooxygenase 1
MSN moesin
MX1 MX dynamin-like GTPase 1
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NELL2 NEL-like 2 (chicken)
NME7 NME/NM23 family member 7
NPTX2 neuronal pentraxin II
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTS neurotensin
NUCB2 nucleobindin 2
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCLO piccolo presynaptic cytomatrix protein
PCP4 Purkinje cell protein 4
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLIN2 perilipin 2
PRAME preferentially expressed antigen in melanoma
PTGIS prostaglandin I2 (prostacyclin) synthase
RBP4 retinol binding protein 4, plasma
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS10 regulator of G-protein signaling 10
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SNAI2 snail family zinc finger 2
SORBS1 sorbin and SH3 domain containing 1
STMN2 stathmin 2
SYNM synemin, intermediate filament protein
SYT1 synaptotagmin I
TAC1 tachykinin, precursor 1
TBX3 T-box 3
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
THBS2 thrombospondin 2
TMEM100 transmembrane protein 100
TMEM204 transmembrane protein 204
TMSB15A thymosin beta 15a
TRIM2 tripartite motif containing 2
TXNDC9 thioredoxin domain containing 9
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VIM vimentin
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
AFG3L2 AFG3-like AAA ATPase 2
AK4 adenylate kinase 4
CCND1 cyclin D1
COL18A1 collagen, type XVIII, alpha 1
COL6A1 collagen, type VI, alpha 1
CXCL13 chemokine (C-X-C motif) ligand 13
EHD1 EH-domain containing 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GLUL glutamate-ammonia ligase
JADE2 jade family PHD finger 2
KCTD12 potassium channel tetramerization domain containing 12
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP2K3 mitogen-activated protein kinase kinase 3
MBP myelin basic protein
MCL1 myeloid cell leukemia 1
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NOP56 NOP56 ribonucleoprotein
OXSR1 oxidative stress responsive 1
PI3 peptidase inhibitor 3, skin-derived
PLA2G15 phospholipase A2, group XV
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPIF peptidylprolyl isomerase F
PRKCD protein kinase C, delta
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SATB1 SATB homeobox 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TACSTD2 tumor-associated calcium signal transducer 2
TATDN2 TatD DNase domain containing 2
TBX2 T-box 2
THAP11 THAP domain containing 11
TKTL1 transketolase-like 1
TPM4 tropomyosin 4
WDR1 WD repeat domain 1
WT1 Wilms tumor 1
ZCCHC2 zinc finger, CCHC domain containing 2