BRD-K89692698_-666_HEPG2_6.0_h_160.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K89692698_-666_HEPG2_6.0_h_160.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
BHLHE40 basic helix-loop-helix family, member e40
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHIC2 cysteine-rich hydrophobic domain 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
ERBB3 erb-b2 receptor tyrosine kinase 3
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GLRX glutaredoxin (thioltransferase)
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
INHBA inhibin, beta A
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP3 matrix metallopeptidase 3
MSMO1 methylsterol monooxygenase 1
NPC1 Niemann-Pick disease, type C1
SC5D sterol-C5-desaturase
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
STC1 stanniocalcin 1
SULF1 sulfatase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRIB3 tribbles pseudokinase 3
VCAN versican
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ARL4A ADP-ribosylation factor-like 4A
ASRGL1 asparaginase like 1
CAV1 caveolin 1, caveolae protein, 22kDa
CKB creatine kinase, brain
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
LAPTM4B lysosomal protein transmembrane 4 beta
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
NELL2 NEL-like 2 (chicken)
PBX3 pre-B-cell leukemia homeobox 3
PCP4 Purkinje cell protein 4
PDE8B phosphodiesterase 8B
PFN2 profilin 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCB protein kinase C, beta
RTN1 reticulon 1
SNX7 sorting nexin 7
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