BRD-K90259198_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K90259198_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM9 ADAM metallopeptidase domain 9
ADAMDEC1 ADAM-like, decysin 1
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ANPEP alanyl (membrane) aminopeptidase
ARG2 arginase 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
BID BH3 interacting domain death agonist
BMP4 bone morphogenetic protein 4
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD40 CD40 molecule, TNF receptor superfamily member 5
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC2 chloride intracellular channel 2
CRABP2 cellular retinoic acid binding protein 2
CXCL11 chemokine (C-X-C motif) ligand 11
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FILIP1L filamin A interacting protein 1-like
FRY furry homolog (Drosophila)
FTH1 ferritin, heavy polypeptide 1
GMPR guanosine monophosphate reductase
HHEX hematopoietically expressed homeobox
HSPA4 heat shock 70kDa protein 4
IDO1 indoleamine 2,3-dioxygenase 1
IL13RA1 interleukin 13 receptor, alpha 1
JCHAIN joining chain of multimeric IgA and IgM
LPAR6 lysophosphatidic acid receptor 6
MAN1A1 mannosidase, alpha, class 1A, member 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NT5E 5'-nucleotidase, ecto (CD73)
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE4A phosphodiesterase 4A, cAMP-specific
PECAM1 platelet/endothelial cell adhesion molecule 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAI14 retinoic acid induced 14
RTN1 reticulon 1
RTN2 reticulon 2
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC38A2 solute carrier family 38, member 2
SNX13 sorting nexin 13
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TESK1 testis-specific kinase 1
TMEM123 transmembrane protein 123
TMSB15A thymosin beta 15a
TRIM2 tripartite motif containing 2
TSPAN12 tetraspanin 12

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANK2 ankyrin 2, neuronal
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
CALML3 calmodulin-like 3
CD24 CD24 molecule
CRYAB crystallin, alpha B
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GPRC5A G protein-coupled receptor, class C, group 5, member A
KRT6B keratin 6B, type II
LY6D lymphocyte antigen 6 complex, locus D
MARCKS myristoylated alanine-rich protein kinase C substrate
PEBP1 phosphatidylethanolamine binding protein 1
PPA1 pyrophosphatase (inorganic) 1
PRDX4 peroxiredoxin 4
QDPR quinoid dihydropteridine reductase
RPS11 ribosomal protein S11
S100A2 S100 calcium binding protein A2
S100B S100 calcium binding protein B
S100P S100 calcium binding protein P
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SPRR2B small proline-rich protein 2B
SRPX sushi-repeat containing protein, X-linked
TFF3 trefoil factor 3 (intestinal)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZCCHC24 zinc finger, CCHC domain containing 24