BRD-K90333595_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

67 genes differentially expressed following the BRD-K90333595_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRG6 adhesion G protein-coupled receptor G6
ALCAM activated leukocyte cell adhesion molecule
AQP3 aquaporin 3 (Gill blood group)
CD163 CD163 molecule
CTSB cathepsin B
CXADR coxsackie virus and adenovirus receptor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DIO2 deiodinase, iodothyronine, type II
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
FAM134B family with sequence similarity 134, member B
FKBP5 FK506 binding protein 5
HBB hemoglobin, beta
IFI6 interferon, alpha-inducible protein 6
KANK1 KN motif and ankyrin repeat domains 1
LIMCH1 LIM and calponin homology domains 1
LZTFL1 leucine zipper transcription factor-like 1
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MYOF myoferlin
NKX2-1 NK2 homeobox 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
S100A11 S100 calcium binding protein A11
SATB1 SATB homeobox 1
SDC4 syndecan 4
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SPATS2L spermatogenesis associated, serine-rich 2-like
TACSTD2 tumor-associated calcium signal transducer 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSC22D1 TSC22 domain family, member 1

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANPEP alanyl (membrane) aminopeptidase
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FLI1 Fli-1 proto-oncogene, ETS transcription factor
HMGB2 high mobility group box 2
HOXB2 homeobox B2
IGHM immunoglobulin heavy constant mu
MDK midkine (neurite growth-promoting factor 2)
MSX1 msh homeobox 1
NMU neuromedin U
NSG1 neuron specific gene family member 1
PEG10 paternally expressed 10
PLA1A phospholipase A1 member A
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
TUBB2A tubulin, beta 2A class IIa
WARS tryptophanyl-tRNA synthetase