BRD-K90382497_GW-843682X_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

192 genes differentially expressed following the BRD-K90382497_GW-843682X_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADRB2 adrenoceptor beta 2, surface
ARG2 arginase 2
ARL4A ADP-ribosylation factor-like 4A
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BTG3 BTG family, member 3
C2CD2 C2 calcium-dependent domain containing 2
CBS cystathionine-beta-synthase
CCDC86 coiled-coil domain containing 86
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTSZ cathepsin Z
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYR61 cysteine-rich, angiogenic inducer, 61
DLC1 DLC1 Rho GTPase activating protein
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
FAM129A family with sequence similarity 129, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FSTL1 follistatin-like 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HIRA histone cell cycle regulator
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDO1 indoleamine 2,3-dioxygenase 1
IFRD1 interferon-related developmental regulator 1
IL6 interleukin 6
JMJD6 jumonji domain containing 6
KCTD5 potassium channel tetramerization domain containing 5
KLF4 Kruppel-like factor 4 (gut)
LRRC59 leucine rich repeat containing 59
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MT1E metallothionein 1E
MT1M metallothionein 1M
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
P3H2 prolyl 3-hydroxylase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSAT1 phosphoserine aminotransferase 1
RAD23B RAD23 homolog B (S. cerevisiae)
REXO2 RNA exonuclease 2
RGS10 regulator of G-protein signaling 10
SDC2 syndecan 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOD2 superoxide dismutase 2, mitochondrial
STAR steroidogenic acute regulatory protein
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TRIB3 tribbles pseudokinase 3
WARS tryptophanyl-tRNA synthetase
WWC2 WW and C2 domain containing 2

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
AHR aryl hydrocarbon receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AQP3 aquaporin 3 (Gill blood group)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATXN1 ataxin 1
BCHE butyrylcholinesterase
CCNE2 cyclin E2
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPF centromere protein F, 350/400kDa
CLCA2 chloride channel accessory 2
COL3A1 collagen, type III, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CRYL1 crystallin, lambda 1
CTSK cathepsin K
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
DCN decorin
DPYD dihydropyrimidine dehydrogenase
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
ERBB3 erb-b2 receptor tyrosine kinase 3
ERGIC3 ERGIC and golgi 3
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAR2 fatty acyl CoA reductase 2
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAS7 growth arrest-specific 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPAA1 glycosylphosphatidylinositol anchor attachment 1
GPSM2 G-protein signaling modulator 2
H1F0 H1 histone family, member 0
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGAV integrin, alpha V
KDM5B lysine (K)-specific demethylase 5B
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA1033 KIAA1033
KIF11 kinesin family member 11
KRT14 keratin 14, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3 lectin, galactoside-binding, soluble, 3
LUM lumican
LY6D lymphocyte antigen 6 complex, locus D
MAGED1 melanoma antigen family D1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
METRN meteorin, glial cell differentiation regulator
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MREG melanoregulin
NAV2 neuron navigator 2
NISCH nischarin
NPIPB3 nuclear pore complex interacting protein family, member B3
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCP4 Purkinje cell protein 4
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZRN3 PDZ domain containing ring finger 3
PERP PERP, TP53 apoptosis effector
PLIN2 perilipin 2
PLP1 proteolipid protein 1
PON3 paraoxonase 3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PUF60 poly-U binding splicing factor 60KDa
RACGAP1 Rac GTPase activating protein 1
RNASE4 ribonuclease, RNase A family, 4
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A7 S100 calcium binding protein A7
S100B S100 calcium binding protein B
SEPP1 selenoprotein P, plasma, 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
SQRDL sulfide quinone reductase-like (yeast)
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SULF1 sulfatase 1
SVIL supervillin
TACSTD2 tumor-associated calcium signal transducer 2
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMEM2 transmembrane protein 2
TMEM45A transmembrane protein 45A
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TUG1 taurine up-regulated 1 (non-protein coding)
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
WWTR1 WW domain containing transcription regulator 1
Funding