BRD-K90382497_GW-843682X_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K90382497_GW-843682X_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AFP alpha-fetoprotein
AHSG alpha-2-HS-glycoprotein
AKIRIN1 akirin 1
ALB albumin
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
APOA2 apolipoprotein A-II
APOB apolipoprotein B
APOH apolipoprotein H (beta-2-glycoprotein I)
ARG2 arginase 2
ATF5 activating transcription factor 5
AURKA aurora kinase A
CA12 carbonic anhydrase XII
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
COL2A1 collagen, type II, alpha 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
FHL1 four and a half LIM domains 1
GAS2L1 growth arrest-specific 2 like 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
JMJD6 jumonji domain containing 6
KIF14 kinesin family member 14
KIF5C kinesin family member 5C
LRRC59 leucine rich repeat containing 59
MFAP3L microfibrillar-associated protein 3-like
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MPPED2 metallophosphoesterase domain containing 2
NEK2 NIMA-related kinase 2
NELL2 NEL-like 2 (chicken)
PDLIM5 PDZ and LIM domain 5
PLK1 polo-like kinase 1
RGS10 regulator of G-protein signaling 10
RTCA RNA 3'-terminal phosphate cyclase
SCRG1 stimulator of chondrogenesis 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SMTN smoothelin
TBL1X transducin (beta)-like 1X-linked
TCL1A T-cell leukemia/lymphoma 1A
TF transferrin
TFF1 trefoil factor 1
TRAPPC3 trafficking protein particle complex 3
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANOS1 anosmin 1
ANXA4 annexin A4
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
C8ORF4 chromosome 8 open reading frame 4
CCNE2 cyclin E2
CD47 CD47 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COMT catechol-O-methyltransferase
CYB5A cytochrome b5 type A (microsomal)
DCN decorin
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EFR3A EFR3 homolog A (S. cerevisiae)
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
FRY furry homolog (Drosophila)
G6PD glucose-6-phosphate dehydrogenase
GPNMB glycoprotein (transmembrane) nmb
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXA5 homeobox A5
INA internexin neuronal intermediate filament protein, alpha
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KLHL9 kelch-like family member 9
KRT7 keratin 7, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LIMCH1 LIM and calponin homology domains 1
LUM lumican
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGED1 melanoma antigen family D1
MCL1 myeloid cell leukemia 1
MEGF9 multiple EGF-like-domains 9
MMP7 matrix metallopeptidase 7
MN1 meningioma (disrupted in balanced translocation) 1
MPO myeloperoxidase
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYH10 myosin, heavy chain 10, non-muscle
NAMPT nicotinamide phosphoribosyltransferase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFL neurofilament, light polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NREP neuronal regeneration related protein
PARP2 poly (ADP-ribose) polymerase 2
PLS1 plastin 1
PNMA2 paraneoplastic Ma antigen 2
PRAME preferentially expressed antigen in melanoma
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RHOBTB1 Rho-related BTB domain containing 1
S100A8 S100 calcium binding protein A8
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SFTPD surfactant protein D
SLC38A2 solute carrier family 38, member 2
SPP1 secreted phosphoprotein 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS2 thrombospondin 2
TM4SF1 transmembrane 4 L six family member 1
TUSC3 tumor suppressor candidate 3
VAT1 vesicle amine transport 1
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
Funding