BRD-K91145395_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

172 genes differentially expressed following the BRD-K91145395_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AMIGO2 adhesion molecule with Ig-like domain 2
AMPD3 adenosine monophosphate deaminase 3
ANO1 anoctamin 1, calcium activated chloride channel
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCL2A1 BCL2-related protein A1
BCL3 B-cell CLL/lymphoma 3
BGN biglycan
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD83 CD83 molecule
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHMP2A charged multivesicular body protein 2A
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSS cathepsin S
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EHD1 EH-domain containing 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
G0S2 G0/G1 switch 2
GABARAPL2 GABA(A) receptor-associated protein-like 2
GCH1 GTP cyclohydrolase 1
GREM1 gremlin 1, DAN family BMP antagonist
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IL11 interleukin 11
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL32 interleukin 32
IL4R interleukin 4 receptor
IL6 interleukin 6
INHBA inhibin, beta A
JUNB jun B proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF5 Kruppel-like factor 5 (intestinal)
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LIF leukemia inhibitory factor
LPXN leupaxin
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MAP7 microtubule-associated protein 7
MARCKSL1 MARCKS-like 1
MET MET proto-oncogene, receptor tyrosine kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MTMR11 myotubularin related protein 11
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NNMT nicotinamide N-methyltransferase
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
ODC1 ornithine decarboxylase 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PNP purine nucleoside phosphorylase
PRSS21 protease, serine, 21 (testisin)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RIPK2 receptor-interacting serine-threonine kinase 2
RNF19B ring finger protein 19B
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SELE selectin E
SGK1 serum/glucocorticoid regulated kinase 1
SLC35F2 solute carrier family 35, member F2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SRI sorcin
STC1 stanniocalcin 1
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAGLN2 transgelin 2
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNIP1 TNFAIP3 interacting protein 1
TRAF1 TNF receptor-associated factor 1
TRIB1 tribbles pseudokinase 1
TXNRD1 thioredoxin reductase 1
VCAM1 vascular cell adhesion molecule 1
VEGFC vascular endothelial growth factor C
VNN1 vanin 1
WIF1 WNT inhibitory factor 1
WTAP Wilms tumor 1 associated protein
ZC3H12A zinc finger CCCH-type containing 12A

decreased expression

Symbol Name
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CELF2 CUGBP, Elav-like family member 2
CHRDL1 chordin-like 1
DUOX2 dual oxidase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FLRT2 fibronectin leucine rich transmembrane protein 2
GPC4 glypican 4
HLTF helicase-like transcription factor
LAMA4 laminin, alpha 4
LEPR leptin receptor
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MBNL2 muscleblind-like splicing regulator 2
MTDH metadherin
NID1 nidogen 1
OAT ornithine aminotransferase
PEG3 paternally expressed 3
PLAC8 placenta-specific 8
PLN phospholamban
PPARG peroxisome proliferator-activated receptor gamma
PRUNE2 prune homolog 2 (Drosophila)
RPL37A ribosomal protein L37a
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SRPX sushi-repeat containing protein, X-linked
TBC1D16 TBC1 domain family, member 16
TWIST1 twist family bHLH transcription factor 1