BRD-K91145395_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

228 genes differentially expressed following the BRD-K91145395_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AKAP12 A kinase (PRKA) anchor protein 12
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ATF3 activating transcription factor 3
ATP13A3 ATPase type 13A3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL10 B-cell CLL/lymphoma 10
BCL2A1 BCL2-related protein A1
BHLHE40 basic helix-loop-helix family, member e40
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C3ORF52 chromosome 3 open reading frame 52
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDC42 cell division cycle 42
CDKN2A cyclin-dependent kinase inhibitor 2A
CFLAR CASP8 and FADD-like apoptosis regulator
CHIC2 cysteine-rich hydrophobic domain 2
CLDN4 claudin 4
CLIC4 chloride intracellular channel 4
CLTB clathrin, light chain B
CORO1C coronin, actin binding protein, 1C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EHD1 EH-domain containing 1
ELL2 elongation factor, RNA polymerase II, 2
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM3C family with sequence similarity 3, member C
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
GPR137B G protein-coupled receptor 137B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
IL11 interleukin 11
IL1RL1 interleukin 1 receptor-like 1
IL4R interleukin 4 receptor
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAV integrin, alpha V
JAG1 jagged 1
JUNB jun B proto-oncogene
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KPNA4 karyopherin alpha 4 (importin alpha 3)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KRT81 keratin 81, type II
KYNU kynureninase
LAMC2 laminin, gamma 2
LIF leukemia inhibitory factor
LRP10 low density lipoprotein receptor-related protein 10
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MT1G metallothionein 1G
NAMPT nicotinamide phosphoribosyltransferase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NMB neuromedin B
NPC1 Niemann-Pick disease, type C1
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
PDLIM5 PDZ and LIM domain 5
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLK3 polo-like kinase 3
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PRKCD protein kinase C, delta
PRNP prion protein
PRR7 proline rich 7 (synaptic)
PTN pleiotrophin
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RIPK2 receptor-interacting serine-threonine kinase 2
RND1 Rho family GTPase 1
RNF167 ring finger protein 167
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SEC24A SEC24 family member A
SELE selectin E
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAD3 SMAD family member 3
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STK17A serine/threonine kinase 17a
STX12 syntaxin 12
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIAM1 T-cell lymphoma invasion and metastasis 1
TICAM1 toll-like receptor adaptor molecule 1
TJP2 tight junction protein 2
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNIP1 TNFAIP3 interacting protein 1
TOMM34 translocase of outer mitochondrial membrane 34
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
TXNRD1 thioredoxin reductase 1
UBL3 ubiquitin-like 3
UGCG UDP-glucose ceramide glucosyltransferase
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
ZC3H12A zinc finger CCCH-type containing 12A

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AMIGO2 adhesion molecule with Ig-like domain 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARMCX2 armadillo repeat containing, X-linked 2
C14ORF132 chromosome 14 open reading frame 132
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CASP6 caspase 6, apoptosis-related cysteine peptidase
CBR4 carbonyl reductase 4
CBS cystathionine-beta-synthase
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES2 carboxylesterase 2
CLDN10 claudin 10
DENND1B DENN/MADD domain containing 1B
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMD dystrophin
DOK5 docking protein 5
EHD3 EH-domain containing 3
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
FABP1 fatty acid binding protein 1, liver
FBXO9 F-box protein 9
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR3 fibroblast growth factor receptor 3
FLRT2 fibronectin leucine rich transmembrane protein 2
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GRHPR glyoxylate reductase/hydroxypyruvate reductase
HEPH hephaestin
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFITM1 interferon induced transmembrane protein 1
ITM2A integral membrane protein 2A
KCTD12 potassium channel tetramerization domain containing 12
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
NDN necdin, melanoma antigen (MAGE) family member
NID2 nidogen 2 (osteonidogen)
NQO2 NAD(P)H dehydrogenase, quinone 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
PRUNE2 prune homolog 2 (Drosophila)
PSPH phosphoserine phosphatase
PXDN peroxidasin
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SORBS3 sorbin and SH3 domain containing 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX11 SRY (sex determining region Y)-box 11
TF transferrin
TNNT1 troponin T type 1 (skeletal, slow)
TNS1 tensin 1
TPM2 tropomyosin 2 (beta)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
VCAN versican
WFS1 Wolfram syndrome 1 (wolframin)
ZNF423 zinc finger protein 423
Funding