BRD-K91145395_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K91145395_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ANO1 anoctamin 1, calcium activated chloride channel
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC3 baculoviral IAP repeat containing 3
CA1 carbonic anhydrase I
CAB39 calcium binding protein 39
CD58 CD58 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLIP1 CAP-GLY domain containing linker protein 1
COL10A1 collagen, type X, alpha 1
COMP cartilage oligomeric matrix protein
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDR1 discoidin domain receptor tyrosine kinase 1
DSP desmoplakin
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GRAMD3 GRAM domain containing 3
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER5 immediate early response 5
IGSF3 immunoglobulin superfamily, member 3
INPP1 inositol polyphosphate-1-phosphatase
ITGAV integrin, alpha V
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
MAPK6 mitogen-activated protein kinase 6
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT2A metallothionein 2A
MYO10 myosin X
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NAMPT nicotinamide phosphoribosyltransferase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2 notch 2
PALLD palladin, cytoskeletal associated protein
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PPARD peroxisome proliferator-activated receptor delta
PROM1 prominin 1
PRSS23 protease, serine, 23
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOF ras homolog family member F (in filopodia)
SDC4 syndecan 4
SFN stratifin
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SPATS2L spermatogenesis associated, serine-rich 2-like
SSFA2 sperm specific antigen 2
STX1A syntaxin 1A (brain)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
WSB2 WD repeat and SOCS box containing 2

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADIRF adipogenesis regulatory factor
BEX1 brain expressed, X-linked 1
BPHL biphenyl hydrolase-like (serine hydrolase)
C4BPA complement component 4 binding protein, alpha
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAST calpastatin
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPA3 carboxypeptidase A3 (mast cell)
DMBT1 deleted in malignant brain tumors 1
EDN1 endothelin 1
GATA2 GATA binding protein 2
GPC3 glypican 3
INTS3 integrator complex subunit 3
KAZN kazrin, periplakin interacting protein
LYZ lysozyme
MAOA monoamine oxidase A
MEIS2 Meis homeobox 2
NARF nuclear prelamin A recognition factor
NCAM1 neural cell adhesion molecule 1
NDNF neuron-derived neurotrophic factor
NEFH neurofilament, heavy polypeptide
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRUNE2 prune homolog 2 (Drosophila)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RCAN2 regulator of calcineurin 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SFTPC surfactant protein C
Funding