BRD-K91263825_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K91263825_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
ACSL3 acyl-CoA synthetase long-chain family member 3
AFF1 AF4/FMR2 family, member 1
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLIC4 chloride intracellular channel 4
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FASN fatty acid synthase
FASTKD5 FAST kinase domains 5
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGB fibrinogen beta chain
FGL2 fibrinogen-like 2
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDI1 isopentenyl-diphosphate delta isomerase 1
IL32 interleukin 32
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
NPC1 Niemann-Pick disease, type C1
NTS neurotensin
PRKCQ protein kinase C, theta
RHOB ras homolog family member B
RNF167 ring finger protein 167
RUFY3 RUN and FYVE domain containing 3
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SQLE squalene epoxidase
TCF4 transcription factor 4
TIMP1 TIMP metallopeptidase inhibitor 1
UGCG UDP-glucose ceramide glucosyltransferase
VCAN versican

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AMIGO2 adhesion molecule with Ig-like domain 2
AUTS2 autism susceptibility candidate 2
BPHL biphenyl hydrolase-like (serine hydrolase)
CADM1 cell adhesion molecule 1
CPE carboxypeptidase E
CXADR coxsackie virus and adenovirus receptor
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FCGBP Fc fragment of IgG binding protein
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
KDM5D lysine (K)-specific demethylase 5D
KRT17 keratin 17, type I
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
MECOM MDS1 and EVI1 complex locus
MMP12 matrix metallopeptidase 12
OLFM4 olfactomedin 4
PAEP progestagen-associated endometrial protein
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TMEM158 transmembrane protein 158 (gene/pseudogene)
TREM1 triggering receptor expressed on myeloid cells 1
Funding