BRD-K91370081_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

275 genes differentially expressed following the BRD-K91370081_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADM adrenomedullin
AKAP13 A kinase (PRKA) anchor protein 13
AKAP8L A kinase (PRKA) anchor protein 8-like
AKIRIN1 akirin 1
ARID4B AT rich interactive domain 4B (RBP1-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BRD2 bromodomain containing 2
C6ORF48 chromosome 6 open reading frame 48
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CCDC59 coiled-coil domain containing 59
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CDKN2AIP CDKN2A interacting protein
CHERP calcium homeostasis endoplasmic reticulum protein
CHI3L2 chitinase 3-like 2
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
COQ10B coenzyme Q10 homolog B (S. cerevisiae)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DIABLO diablo, IAP-binding mitochondrial protein
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECD ecdysoneless homolog (Drosophila)
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR3 early growth response 3
ELF1 E74-like factor 1 (ets domain transcription factor)
FBXO11 F-box protein 11
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GOLGA4 golgin A4
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL6ST interleukin 6 signal transducer
IRF1 interferon regulatory factor 1
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KDM6A lysine (K)-specific demethylase 6A
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LTF lactotransferrin
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NINJ1 ninjurin 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
OLFML2B olfactomedin-like 2B
PELI1 pellino E3 ubiquitin protein ligase 1
PER2 period circadian clock 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMEPA1 prostate transmembrane protein, androgen induced 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSME4 proteasome (prosome, macropain) activator subunit 4
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
RAE1 ribonucleic acid export 1
RBMS1 RNA binding motif, single stranded interacting protein 1
RCOR3 REST corepressor 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RNF10 ring finger protein 10
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSRC2 arginine/serine-rich coiled-coil 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SFRP4 secreted frizzled-related protein 4
SFTPB surfactant protein B
SIK3 SIK family kinase 3
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX4 SRY (sex determining region Y)-box 4
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRRM2 serine/arginine repetitive matrix 2
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
SYNGR3 synaptogyrin 3
TBCE tubulin folding cofactor E
TERF2IP telomeric repeat binding factor 2, interacting protein
TESC tescalcin
TGM2 transglutaminase 2
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TLK2 tousled-like kinase 2
TMEM87A transmembrane protein 87A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOP1 topoisomerase (DNA) I
TRA2A transformer 2 alpha homolog (Drosophila)
TREM1 triggering receptor expressed on myeloid cells 1
TRIM33 tripartite motif containing 33
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
UBAP1 ubiquitin associated protein 1
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
USP47 ubiquitin specific peptidase 47
VCPKMT valosin containing protein lysine (K) methyltransferase
YTHDC1 YTH domain containing 1
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36 ZFP36 ring finger protein
ZMYM2 zinc finger, MYM-type 2
ZNF140 zinc finger protein 140
ZNF24 zinc finger protein 24
ZNF274 zinc finger protein 274
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADARB1 adenosine deaminase, RNA-specific, B1
ADCY9 adenylate cyclase 9
ADIRF adipogenesis regulatory factor
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
B3GNT1
BAG3 BCL2-associated athanogene 3
BCHE butyrylcholinesterase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C14ORF132 chromosome 14 open reading frame 132
C6ORF62 chromosome 6 open reading frame 62
CALD1 caldesmon 1
CAV2 caveolin 2
CBS cystathionine-beta-synthase
CCNA2 cyclin A2
CD200 CD200 molecule
CD24 CD24 molecule
CP ceruloplasmin (ferroxidase)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRP C-reactive protein, pentraxin-related
CSTA cystatin A (stefin A)
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DEFB1 defensin, beta 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPYSL2 dihydropyrimidinase-like 2
DSP desmoplakin
ENDOD1 endonuclease domain containing 1
FCGBP Fc fragment of IgG binding protein
FEN1 flap structure-specific endonuclease 1
FERMT1 fermitin family member 1
FGFR2 fibroblast growth factor receptor 2
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
GJA1 gap junction protein, alpha 1, 43kDa
GLDC glycine dehydrogenase (decarboxylating)
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HMGN4 high mobility group nucleosomal binding domain 4
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA8 heat shock 70kDa protein 8
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JCHAIN joining chain of multimeric IgA and IgM
KANK1 KN motif and ankyrin repeat domains 1
KAZN kazrin, periplakin interacting protein
KCTD12 potassium channel tetramerization domain containing 12
KIAA0930 KIAA0930
MAT2A methionine adenosyltransferase II, alpha
MPZL2 myelin protein zero-like 2
MXRA7 matrix-remodelling associated 7
MYOF myoferlin
NDRG2 NDRG family member 2
NMU neuromedin U
NUP62 nucleoporin 62kDa
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCNA proliferating cell nuclear antigen
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PXDN peroxidasin
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SH3BGRL SH3 domain binding glutamate-rich protein like
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC38A1 solute carrier family 38, member 1
STARD7 StAR-related lipid transfer (START) domain containing 7
SYNM synemin, intermediate filament protein
TBC1D16 TBC1 domain family, member 16
TFDP1 transcription factor Dp-1
THAP11 THAP domain containing 11
TMEM97 transmembrane protein 97
TMPO thymopoietin
TPBG trophoblast glycoprotein
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TST thiosulfate sulfurtransferase (rhodanese)
TUBB tubulin, beta class I
TYMS thymidylate synthetase
Funding