BRD-K91509126_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

49 genes differentially expressed following the BRD-K91509126_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
DDAH1 dimethylarginine dimethylaminohydrolase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
FTH1 ferritin, heavy polypeptide 1
GNAS GNAS complex locus
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IGKV4-1 immunoglobulin kappa variable 4-1
INSIG1 insulin induced gene 1
MAPT microtubule-associated protein tau
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NDRG1 N-myc downstream regulated 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SULF1 sulfatase 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNIP1 TNFAIP3 interacting protein 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ATM ATM serine/threonine kinase
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
CCND2 cyclin D2
CD24 CD24 molecule
COL5A2 collagen, type V, alpha 2
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGF13 fibroblast growth factor 13
FGFR2 fibroblast growth factor receptor 2
GSN gelsolin
HMG20B high mobility group 20B
HMGB3 high mobility group box 3
HOPX HOP homeobox
IGFBP5 insulin-like growth factor binding protein 5
ISOC1 isochorismatase domain containing 1
NGRN neugrin, neurite outgrowth associated
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
QKI QKI, KH domain containing, RNA binding
QPCT glutaminyl-peptide cyclotransferase
SCUBE2 signal peptide, CUB domain, EGF-like 2
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase