BRD-K91781484_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K91781484_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
CBR3 carbonyl reductase 3
CD200 CD200 molecule
CD69 CD69 molecule
CTSB cathepsin B
CXCL8 chemokine (C-X-C motif) ligand 8
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
HACD1 3-hydroxyacyl-CoA dehydratase 1
HMOX1 heme oxygenase 1
IGL immunoglobulin lambda locus
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NAMPT nicotinamide phosphoribosyltransferase
NPR3 natriuretic peptide receptor 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
PDLIM5 PDZ and LIM domain 5
PERP PERP, TP53 apoptosis effector
PGD phosphogluconate dehydrogenase
PHACTR2 phosphatase and actin regulator 2
PIR pirin (iron-binding nuclear protein)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLS3 plastin 3
S100A8 S100 calcium binding protein A8
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELL selectin L
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TALDO1 transaldolase 1
TKT transketolase
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPD52L1 tumor protein D52-like 1
TRBC1 T cell receptor beta constant 1
TRIM16 tripartite motif containing 16
TXNRD1 thioredoxin reductase 1
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
EPB41L3 erythrocyte membrane protein band 4.1-like 3
HES1 hes family bHLH transcription factor 1
HNMT histamine N-methyltransferase
LCN2 lipocalin 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
PDZK1IP1 PDZK1 interacting protein 1
PLAT plasminogen activator, tissue
RIN2 Ras and Rab interactor 2
SPINK1 serine peptidase inhibitor, Kazal type 1
THAP11 THAP domain containing 11
TIMP1 TIMP metallopeptidase inhibitor 1
TKTL1 transketolase-like 1
TMEM100 transmembrane protein 100
XIST X inactive specific transcript (non-protein coding)
Funding