BRD-K91937579_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K91937579_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOLD1 apolipoprotein L domain containing 1
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
CD24 CD24 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CNPY3 canopy FGF signaling regulator 3
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP6 fatty acid binding protein 6, ileal
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GCLC glutamate-cysteine ligase, catalytic subunit
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
JUN jun proto-oncogene
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KIAA0226L KIAA0226-like
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEIS2 Meis homeobox 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRR7 proline rich 7 (synaptic)
PRSS3 protease, serine, 3
PSPH phosphoserine phosphatase
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SOX11 SRY (sex determining region Y)-box 11
STC2 stanniocalcin 2
TCL1A T-cell leukemia/lymphoma 1A
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSC22D1 TSC22 domain family, member 1
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AZU1 azurocidin 1
CALR calreticulin
CAST calpastatin
CCNF cyclin F
CHL1 cell adhesion molecule L1-like
DEFB1 defensin, beta 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FRZB frizzled-related protein
GOLGA8A golgin A8 family, member A
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGKV1-5 immunoglobulin kappa variable 1-5
IQGAP2 IQ motif containing GTPase activating protein 2
KIAA0907 KIAA0907
LAPTM4B lysosomal protein transmembrane 4 beta
LPCAT1 lysophosphatidylcholine acyltransferase 1
MEGF9 multiple EGF-like-domains 9
MFAP3L microfibrillar-associated protein 3-like
MXRA5 matrix-remodelling associated 5
NR2F2 nuclear receptor subfamily 2, group F, member 2
S100P S100 calcium binding protein P
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNIP1 TNFAIP3 interacting protein 1
TUBB2A tubulin, beta 2A class IIa
Funding