BRD-K92241597_CHR 2797_MDST8_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K92241597_CHR 2797_MDST8_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACSL1 acyl-CoA synthetase long-chain family member 1
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BLVRB biliverdin reductase B
C10ORF10 chromosome 10 open reading frame 10
C1ORF116 chromosome 1 open reading frame 116
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CELF2 CUGBP, Elav-like family member 2
CFH complement factor H
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CSNK1A1 casein kinase 1, alpha 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EMP1 epithelial membrane protein 1
FAM129A family with sequence similarity 129, member A
FOXO1 forkhead box O1
GDF15 growth differentiation factor 15
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA2 heat shock 70kDa protein 2
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFIH1 interferon induced with helicase C domain 1
IFITM1 interferon induced transmembrane protein 1
IGFBP6 insulin-like growth factor binding protein 6
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
ISG15 ISG15 ubiquitin-like modifier
KLHDC10 kelch domain containing 10
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MSX1 msh homeobox 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MX1 MX dynamin-like GTPase 1
NFIL3 nuclear factor, interleukin 3 regulated
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PELI1 pellino E3 ubiquitin protein ligase 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRKCH protein kinase C, eta
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
S100A2 S100 calcium binding protein A2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPON2 spondin 2, extracellular matrix protein
SRPX2 sushi-repeat containing protein, X-linked 2
TMSB15A thymosin beta 15a
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
USP6NL USP6 N-terminal like
YBX3 Y box binding protein 3
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ADD3 adducin 3 (gamma)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA2 annexin A2
ATF5 activating transcription factor 5
C7 complement component 7
CCL19 chemokine (C-C motif) ligand 19
CDC25A cell division cycle 25A
CHMP4A charged multivesicular body protein 4A
CLIC4 chloride intracellular channel 4
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTL1 cytokine-like 1
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EZR ezrin
FBP1 fructose-1,6-bisphosphatase 1
FBXO21 F-box protein 21
FHL1 four and a half LIM domains 1
GALC galactosylceramidase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLIPR1 GLI pathogenesis-related 1
HRSP12 heat-responsive protein 12
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LUM lumican
LYZ lysozyme
MAP7 microtubule-associated protein 7
MFSD10 major facilitator superfamily domain containing 10
OLFM4 olfactomedin 4
PARM1 prostate androgen-regulated mucin-like protein 1
PDZK1 PDZ domain containing 1
PLAT plasminogen activator, tissue
PNMA2 paraneoplastic Ma antigen 2
POSTN periostin, osteoblast specific factor
PROM1 prominin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
S100A8 S100 calcium binding protein A8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SOX2 SRY (sex determining region Y)-box 2
SOX4 SRY (sex determining region Y)-box 4
SRGN serglycin
SST somatostatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TUBA1A tubulin, alpha 1a
ZMYND8 zinc finger, MYND-type containing 8