BRD-K92241597_CHR 2797_VCAP_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K92241597_CHR 2797_VCAP_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACSL1 acyl-CoA synthetase long-chain family member 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
CAST calpastatin
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CLU clusterin
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSG3 desmoglein 3
ECM1 extracellular matrix protein 1
FDPS farnesyl diphosphate synthase
GPM6B glycoprotein M6B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KLF9 Kruppel-like factor 9
KRT5 keratin 5, type II
LDLR low density lipoprotein receptor
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC5B mucin 5B, oligomeric mucus/gel-forming
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NPC1 Niemann-Pick disease, type C1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4DIP phosphodiesterase 4D interacting protein
PKP1 plakophilin 1
PSAT1 phosphoserine aminotransferase 1
PTN pleiotrophin
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
CCDC86 coiled-coil domain containing 86
CD200 CD200 molecule
CD93 CD93 molecule
COL9A2 collagen, type IX, alpha 2
CTSH cathepsin H
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DPH2 DPH2 homolog (S. cerevisiae)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4A1 eukaryotic translation initiation factor 4A1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FAR2 fatty acyl CoA reductase 2
FBP1 fructose-1,6-bisphosphatase 1
FKBP10 FK506 binding protein 10, 65 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GATA2 GATA binding protein 2
GPRC5B G protein-coupled receptor, class C, group 5, member B
IGFBP3 insulin-like growth factor binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
LAMP5 lysosomal-associated membrane protein family, member 5
MAT2A methionine adenosyltransferase II, alpha
MCAM melanoma cell adhesion molecule
MRPL17 mitochondrial ribosomal protein L17
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCBP2 nuclear cap binding protein subunit 2, 20kDa
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOP56 NOP56 ribonucleoprotein
PLAT plasminogen activator, tissue
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
POLR1C polymerase (RNA) I polypeptide C, 30kDa
POSTN periostin, osteoblast specific factor
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SNX10 sorting nexin 10
SPP1 secreted phosphoprotein 1
SRSF7 serine/arginine-rich splicing factor 7
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TMSB15A thymosin beta 15a
TUBB6 tubulin, beta 6 class V