BRD-K92317137_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

327 genes differentially expressed following the BRD-K92317137_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
ARC activity-regulated cytoskeleton-associated protein
ARID4B AT rich interactive domain 4B (RBP1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AXIN1 axin 1
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BCHE butyrylcholinesterase
BHLHE40 basic helix-loop-helix family, member e40
BIK BCL2-interacting killer (apoptosis-inducing)
BLNK B-cell linker
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CBX4 chromobox homolog 4
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHD1 chromodomain helicase DNA binding protein 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
COL6A2 collagen, type VI, alpha 2
CSRP1 cysteine and glycine-rich protein 1
CTH cystathionine gamma-lyase
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLC1 DLC1 Rho GTPase activating protein
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DLK1 delta-like 1 homolog (Drosophila)
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DOK5 docking protein 5
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFHD1 EF-hand domain family, member D1
EFNA1 ephrin-A1
EFNB2 ephrin-B2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5 eukaryotic translation initiation factor 5
ELOVL5 ELOVL fatty acid elongase 5
EMP1 epithelial membrane protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
FAM53C family with sequence similarity 53, member C
FASN fatty acid synthase
FEM1C fem-1 homolog c (C. elegans)
FERMT2 fermitin family member 2
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA2 GATA binding protein 2
GEM GTP binding protein overexpressed in skeletal muscle
GLA galactosidase, alpha
GLRX glutaredoxin (thioltransferase)
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2BK histone cluster 1, H2bk
HLA-E major histocompatibility complex, class I, E
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL11 interleukin 11
IL6 interleukin 6
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KDM6B lysine (K)-specific demethylase 6B
KDM7A lysine (K)-specific demethylase 7A
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LBH limb bud and heart development
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LIF leukemia inhibitory factor
LXN latexin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
MSX1 msh homeobox 1
MT1M metallothionein 1M
MTSS1 metastasis suppressor 1
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NDRG4 NDRG family member 4
NEFM neurofilament, medium polypeptide
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NOTCH1 notch 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
PCDH9 protocadherin 9
PDGFA platelet-derived growth factor alpha polypeptide
PDZD2 PDZ domain containing 2
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRF1 perforin 1 (pore forming protein)
PRKCA protein kinase C, alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
PTPRE protein tyrosine phosphatase, receptor type, E
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RND1 Rho family GTPase 1
RNF103 ring finger protein 103
RNMT RNA (guanine-7-) methyltransferase
S100A10 S100 calcium binding protein A10
S100A11 S100 calcium binding protein A11
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELE selectin E
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMOX spermine oxidase
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPAG9 sperm associated antigen 9
SPON2 spondin 2, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY4 sprouty homolog 4 (Drosophila)
STAR steroidogenic acute regulatory protein
STC1 stanniocalcin 1
STK10 serine/threonine kinase 10
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBD thrombomodulin
THBS4 thrombospondin 4
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGCG UDP-glucose ceramide glucosyltransferase
UGDH UDP-glucose 6-dehydrogenase
XBP1 X-box binding protein 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YPEL5 yippee-like 5 (Drosophila)
ZBTB10 zinc finger and BTB domain containing 10
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ABHD10 abhydrolase domain containing 10
AGTR1 angiotensin II receptor, type 1
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
AP3M2 adaptor-related protein complex 3, mu 2 subunit
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARMC1 armadillo repeat containing 1
AURKA aurora kinase A
B3GNT1
BOP1 block of proliferation 1
C2CD5 C2 calcium-dependent domain containing 5
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNF cyclin F
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CSRP2 cysteine and glycine-rich protein 2
CYC1 cytochrome c-1
DCT dopachrome tautomerase
DDB2 damage-specific DNA binding protein 2, 48kDa
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
DYNLT3 dynein, light chain, Tctex-type 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFR3A EFR3 homolog A (S. cerevisiae)
EI24 etoposide induced 2.4
ERLIN2 ER lipid raft associated 2
EXOSC4 exosome component 4
FBLN1 fibulin 1
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLOD4 glyoxalase domain containing 4
GNAS GNAS complex locus
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPSM2 G-protein signaling modulator 2
GSTP1 glutathione S-transferase pi 1
HMGA2 high mobility group AT-hook 2
ICMT isoprenylcysteine carboxyl methyltransferase
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS1 insulin receptor substrate 1
KANK1 KN motif and ankyrin repeat domains 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LONP1 lon peptidase 1, mitochondrial
LRRC47 leucine rich repeat containing 47
LY6E lymphocyte antigen 6 complex, locus E
LYPLA1 lysophospholipase I
METTL17 methyltransferase like 17
METTL3 methyltransferase like 3
METTL7A methyltransferase like 7A
MFAP4 microfibrillar-associated protein 4
MRPL15 mitochondrial ribosomal protein L15
MRPL17 mitochondrial ribosomal protein L17
MRPL34 mitochondrial ribosomal protein L34
MRPS28 mitochondrial ribosomal protein S28
MX2 MX dynamin-like GTPase 2
NAV2 neuron navigator 2
NBN nibrin
NPY neuropeptide Y
NUDCD3 NudC domain containing 3
NUP62 nucleoporin 62kDa
OXLD1 oxidoreductase-like domain containing 1
PARP2 poly (ADP-ribose) polymerase 2
PLK1 polo-like kinase 1
POGLUT1 protein O-glucosyltransferase 1
PON2 paraoxonase 2
PRSS23 protease, serine, 23
RAD51C RAD51 paralog C
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPP38 ribonuclease P/MRP 38kDa subunit
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRAGA Ras-related GTP binding A
RRP1B ribosomal RNA processing 1B
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC25A46 solute carrier family 25, member 46
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TACC3 transforming, acidic coiled-coil containing protein 3
TCEA1 transcription elongation factor A (SII), 1
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM223 transmembrane protein 223
TMF1 TATA element modulatory factor 1
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC3 trafficking protein particle complex 3
UMPS uridine monophosphate synthetase
ZDHHC13 zinc finger, DHHC-type containing 13
ZMYM3 zinc finger, MYM-type 3
ZNF706 zinc finger protein 706
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