BRD-K92317137_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

390 genes differentially expressed following the BRD-K92317137_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
AKAP17A A kinase (PRKA) anchor protein 17A
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD12 ankyrin repeat domain 12
ARC activity-regulated cytoskeleton-associated protein
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATMIN ATM interactor
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
AVPI1 arginine vasopressin-induced 1
AXL AXL receptor tyrosine kinase
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BIN1 bridging integrator 1
BMP2 bone morphogenetic protein 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDA cytidine deaminase
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CES1 carboxylesterase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHMP1B charged multivesicular body protein 1B
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
CLIC4 chloride intracellular channel 4
CST3 cystatin C
CTGF connective tissue growth factor
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEFB4A defensin, beta 4A
DFNA5 deafness, autosomal dominant 5
DIO2 deiodinase, iodothyronine, type II
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DMBT1 deleted in malignant brain tumors 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EGR3 early growth response 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5 eukaryotic translation initiation factor 5
ELANE elastase, neutrophil expressed
ELL2 elongation factor, RNA polymerase II, 2
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FHL2 four and a half LIM domains 2
FNDC3B fibronectin type III domain containing 3B
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXN3 forkhead box N3
FOXO3 forkhead box O3
FXR1 fragile X mental retardation, autosomal homolog 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GLIPR1 GLI pathogenesis-related 1
GOLM1 golgi membrane protein 1
HAL histidine ammonia-lyase
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IL1R2 interleukin 1 receptor, type II
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5A lysine (K)-specific demethylase 5A
KDM6B lysine (K)-specific demethylase 6B
KDM7A lysine (K)-specific demethylase 7A
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LAPTM4B lysosomal protein transmembrane 4 beta
LBH limb bud and heart development
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
LMO4 LIM domain only 4
LOX lysyl oxidase
LPAR1 lysophosphatidic acid receptor 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MAPK6 mitogen-activated protein kinase 6
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLF1 myeloid leukemia factor 1
MSLN mesothelin
MSX1 msh homeobox 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MT1X metallothionein 1X
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXI1 MAX interactor 1, dimerization protein
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NUPL1 nucleoporin like 1
OSBPL1A oxysterol binding protein-like 1A
OSER1 oxidative stress responsive serine-rich 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM4 PDZ and LIM domain 4
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
PLAUR plasminogen activator, urokinase receptor
PLTP phospholipid transfer protein
PMEPA1 prostate transmembrane protein, androgen induced 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTHLH parathyroid hormone-like hormone
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTX3 pentraxin 3, long
RAB31 RAB31, member RAS oncogene family
RB1CC1 RB1-inducible coiled-coil 1
RGCC regulator of cell cycle
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
RNMT RNA (guanine-7-) methyltransferase
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SCG5 secretogranin V
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD2 SERTA domain containing 2
SFN stratifin
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A2 solute carrier family 38, member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMOX spermine oxidase
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNAI2 snail family zinc finger 2
SOCS3 suppressor of cytokine signaling 3
SOWAHC sosondowah ankyrin repeat domain family member C
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SSFA2 sperm specific antigen 2
STX3 syntaxin 3
TAL1 T-cell acute lymphocytic leukemia 1
TBP TATA box binding protein
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TES testin LIM domain protein
TGFBI transforming growth factor, beta-induced, 68kDa
THBD thrombomodulin
TICAM1 toll-like receptor adaptor molecule 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM45A transmembrane protein 45A
TNPO1 transportin 1
TPD52 tumor protein D52
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBXN7 UBX domain protein 7
UFM1 ubiquitin-fold modifier 1
UPP1 uridine phosphorylase 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VEGFA vascular endothelial growth factor A
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
VWF von Willebrand factor
WBP5 WW domain binding protein 5
WNT5A wingless-type MMTV integration site family, member 5A
ZBTB16 zinc finger and BTB domain containing 16
ZBTB38 zinc finger and BTB domain containing 38
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZMIZ1 zinc finger, MIZ-type containing 1
ZMYND8 zinc finger, MYND-type containing 8
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIM1 absent in melanoma 1
AKAP1 A kinase (PRKA) anchor protein 1
ALB albumin
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
APOH apolipoprotein H (beta-2-glycoprotein I)
APP amyloid beta (A4) precursor protein
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX2 armadillo repeat containing, X-linked 2
ARMT1 acidic residue methyltransferase 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BMP4 bone morphogenetic protein 4
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3 complement component 3
C7 complement component 7
CALB1 calbindin 1, 28kDa
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNF cyclin F
CD47 CD47 molecule
CDC25B cell division cycle 25B
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CFB complement factor B
CLIC5 chloride intracellular channel 5
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COA3 cytochrome c oxidase assembly factor 3
COL14A1 collagen, type XIV, alpha 1
COX11 COX11 cytochrome c oxidase copper chaperone
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
DCTPP1 dCTP pyrophosphatase 1
DCXR dicarbonyl/L-xylulose reductase
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
DSP desmoplakin
EHD3 EH-domain containing 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAS Fas cell surface death receptor
FBLN1 fibulin 1
FBXL2 F-box and leucine-rich repeat protein 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
GAS1 growth arrest-specific 1
GMNN geminin, DNA replication inhibitor
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GRB14 growth factor receptor-bound protein 14
GREM1 gremlin 1, DAN family BMP antagonist
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KLK11 kallikrein-related peptidase 11
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LGALS4 lectin, galactoside-binding, soluble, 4
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LMNB1 lamin B1
LY75 lymphocyte antigen 75
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKSL1 MARCKS-like 1
MCM3 minichromosome maintenance complex component 3
MELK maternal embryonic leucine zipper kinase
MRPS30 mitochondrial ribosomal protein S30
MXRA5 matrix-remodelling associated 5
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NOL11 nucleolar protein 11
NPY1R neuropeptide Y receptor Y1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUSAP1 nucleolar and spindle associated protein 1
PCP4 Purkinje cell protein 4
PEBP1 phosphatidylethanolamine binding protein 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
PLXNB2 plexin B2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POSTN periostin, osteoblast specific factor
PPA1 pyrophosphatase (inorganic) 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
RBBP7 retinoblastoma binding protein 7
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEPHS1 selenophosphate synthetase 1
SEPT6 septin 6
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SULF1 sulfatase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMEM30B transmembrane protein 30B
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TRIM14 tripartite motif containing 14
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
VSNL1 visinin-like 1
VTCN1 V-set domain containing T cell activation inhibitor 1
ZNF586 zinc finger protein 586
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