BRD-K92428153_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K92428153_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APLP2 amyloid beta (A4) precursor-like protein 2
APMAP adipocyte plasma membrane associated protein
ATF3 activating transcription factor 3
BLCAP bladder cancer associated protein
BLVRB biliverdin reductase B
BST2 bone marrow stromal cell antigen 2
CCDC85B coiled-coil domain containing 85B
CCDC86 coiled-coil domain containing 86
CCNE2 cyclin E2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
DEPTOR DEP domain containing MTOR-interacting protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIRAS3 DIRAS family, GTP-binding RAS-like 3
ENDOD1 endonuclease domain containing 1
FAS Fas cell surface death receptor
FXYD3 FXYD domain containing ion transport regulator 3
GATA2 GATA binding protein 2
GFOD1 glucose-fructose oxidoreductase domain containing 1
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFI30 interferon, gamma-inducible protein 30
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL17RB interleukin 17 receptor B
LTF lactotransferrin
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MT1M metallothionein 1M
MT2A metallothionein 2A
NDRG1 N-myc downstream regulated 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
PEX11A peroxisomal biogenesis factor 11 alpha
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB2A1 secretoglobin, family 2A, member 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SESN1 sestrin 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SPRY4 sprouty homolog 4 (Drosophila)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF1 activating transcription factor 1
AURKA aurora kinase A
BEX1 brain expressed, X-linked 1
BPTF bromodomain PHD finger transcription factor
C6ORF62 chromosome 6 open reading frame 62
CCNF cyclin F
CD24 CD24 molecule
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CNN3 calponin 3, acidic
COPS7A COP9 signalosome subunit 7A
DDIT4 DNA-damage-inducible transcript 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGFR epidermal growth factor receptor
EREG epiregulin
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FXYD2 FXYD domain containing ion transport regulator 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
INTS3 integrator complex subunit 3
KIF23 kinesin family member 23
NTS neurotensin
PLK1 polo-like kinase 1
SCEL sciellin
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SOX9 SRY (sex determining region Y)-box 9
TFF1 trefoil factor 1
TGFBI transforming growth factor, beta-induced, 68kDa
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TYRP1 tyrosinase-related protein 1