BRD-K92428232_GSK-461364_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K92428232_GSK-461364_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMIGO2 adhesion molecule with Ig-like domain 2
ASS1 argininosuccinate synthase 1
AUTS2 autism susceptibility candidate 2
BAG2 BCL2-associated athanogene 2
BEX1 brain expressed, X-linked 1
BIK BCL2-interacting killer (apoptosis-inducing)
C1S complement component 1, s subcomponent
C3ORF14 chromosome 3 open reading frame 14
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN18 claudin 18
CTSE cathepsin E
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IRS1 insulin receptor substrate 1
ISOC1 isochorismatase domain containing 1
KRT19 keratin 19, type I
KRT4 keratin 4, type II
LGALS4 lectin, galactoside-binding, soluble, 4
LRMP lymphoid-restricted membrane protein
NSDHL NAD(P) dependent steroid dehydrogenase-like
ODC1 ornithine decarboxylase 1
PAWR PRKC, apoptosis, WT1, regulator
RGS2 regulator of G-protein signaling 2
S100P S100 calcium binding protein P
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SQLE squalene epoxidase
SQSTM1 sequestosome 1
TIMP1 TIMP metallopeptidase inhibitor 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VDAC1 voltage-dependent anion channel 1

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AKAP7 A kinase (PRKA) anchor protein 7
ARG1 arginase 1
ARMCX2 armadillo repeat containing, X-linked 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
CA2 carbonic anhydrase II
CCNE2 cyclin E2
CCNF cyclin F
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CIRBP cold inducible RNA binding protein
CPM carboxypeptidase M
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL6 chemokine (C-X-C motif) ligand 6
CYTL1 cytokine-like 1
DPP4 dipeptidyl-peptidase 4
EREG epiregulin
FZD10 frizzled class receptor 10
GOLM1 golgi membrane protein 1
GRB14 growth factor receptor-bound protein 14
GRIA2 glutamate receptor, ionotropic, AMPA 2
HLF hepatic leukemia factor
HOXA5 homeobox A5
IFI6 interferon, alpha-inducible protein 6
IGF1R insulin-like growth factor 1 receptor
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KIAA0125 KIAA0125
KRT10 keratin 10, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LIG1 ligase I, DNA, ATP-dependent
MAP2K6 mitogen-activated protein kinase kinase 6
MPZL2 myelin protein zero-like 2
NEFH neurofilament, heavy polypeptide
NES nestin
NFIB nuclear factor I/B
NLRP2 NLR family, pyrin domain containing 2
NOTCH2NL notch 2 N-terminal like
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
PSPH phosphoserine phosphatase
RBP1 retinol binding protein 1, cellular
RDX radixin
RELN reelin
S100A7 S100 calcium binding protein A7
SCAND1 SCAN domain containing 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SMAD1 SMAD family member 1
SOX9 SRY (sex determining region Y)-box 9
SPTBN1 spectrin, beta, non-erythrocytic 1
SRP72 signal recognition particle 72kDa
SRSF6 serine/arginine-rich splicing factor 6
STMN2 stathmin 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
Funding