BRD-K92428232_GSK-461364_HA1E_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-K92428232_GSK-461364_HA1E_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADD3 adducin 3 (gamma)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AURKA aurora kinase A
BPTF bromodomain PHD finger transcription factor
BRD4 bromodomain containing 4
CA2 carbonic anhydrase II
CD69 CD69 molecule
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLDN3 claudin 3
CLEC2B C-type lectin domain family 2, member B
COCH cochlin
COMP cartilage oligomeric matrix protein
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DPP4 dipeptidyl-peptidase 4
EIF5B eukaryotic translation initiation factor 5B
EREG epiregulin
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPRC5B G protein-coupled receptor, class C, group 5, member B
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIST1H1C histone cluster 1, H1c
INSR insulin receptor
KIF5B kinesin family member 5B
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LUC7L3 LUC7-like 3 (S. cerevisiae)
MTA1 metastasis associated 1
MYLK myosin light chain kinase
NQO1 NAD(P)H dehydrogenase, quinone 1
NT5E 5'-nucleotidase, ecto (CD73)
PEX11A peroxisomal biogenesis factor 11 alpha
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRKCB protein kinase C, beta
PRRC2C proline-rich coiled-coil 2C
PRSS2 protease, serine, 2 (trypsin 2)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RBM25 RNA binding motif protein 25
RGS10 regulator of G-protein signaling 10
RSL1D1 ribosomal L1 domain containing 1
S100A7 S100 calcium binding protein A7
SEC62 SEC62 homolog (S. cerevisiae)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC38A1 solute carrier family 38, member 1
SRP72 signal recognition particle 72kDa
SSB Sjogren syndrome antigen B (autoantigen La)
THOC2 THO complex 2
TIMP3 TIMP metallopeptidase inhibitor 3
TOB1 transducer of ERBB2, 1
ZEB1 zinc finger E-box binding homeobox 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTB actin, beta
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
AGA aspartylglucosaminidase
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANOS1 anosmin 1
APLP2 amyloid beta (A4) precursor-like protein 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
C10ORF10 chromosome 10 open reading frame 10
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CBR3 carbonyl reductase 3
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
COPS7A COP9 signalosome subunit 7A
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP5 dual specificity phosphatase 5
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
FBP1 fructose-1,6-bisphosphatase 1
FCN3 ficolin (collagen/fibrinogen domain containing) 3
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IL32 interleukin 32
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
KRT7 keratin 7, type II
KRT8 keratin 8, type II
L1CAM L1 cell adhesion molecule
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMCD1 LIM and cysteine-rich domains 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MFSD10 major facilitator superfamily domain containing 10
MSH6 mutS homolog 6
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRCAM neuronal cell adhesion molecule
NREP neuronal regeneration related protein
OPN3 opsin 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PNMA2 paraneoplastic Ma antigen 2
RAB7A RAB7A, member RAS oncogene family
RGS4 regulator of G-protein signaling 4
RNASE4 ribonuclease, RNase A family, 4
RNH1 ribonuclease/angiogenin inhibitor 1
S100A11 S100 calcium binding protein A11
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SH3YL1 SH3 and SYLF domain containing 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX4 SRY (sex determining region Y)-box 4
TAGLN2 transgelin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THBS2 thrombospondin 2
UBE2A ubiquitin-conjugating enzyme E2A
USP1 ubiquitin specific peptidase 1
WEE1 WEE1 G2 checkpoint kinase
XPO7 exportin 7
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Funding