BRD-K92571446_WZ-3105_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

171 genes differentially expressed following the BRD-K92571446_WZ-3105_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADD3 adducin 3 (gamma)
ADI1 acireductone dioxygenase 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ASPN asporin
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BMP2 bone morphogenetic protein 2
BSG basigin (Ok blood group)
CALD1 caldesmon 1
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CD46 CD46 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSZ cathepsin Z
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP1 dual specificity phosphatase 1
ECM1 extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL1 four and a half LIM domains 1
FLT1 fms-related tyrosine kinase 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GAA glucosidase, alpha; acid
GADD45A growth arrest and DNA-damage-inducible, alpha
GPX1 glutathione peroxidase 1
GSN gelsolin
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
H2AFV H2A histone family, member V
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-F major histocompatibility complex, class I, F
HNRNPL heterogeneous nuclear ribonucleoprotein L
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL1RN interleukin 1 receptor antagonist
IL7R interleukin 7 receptor
JAG1 jagged 1
KRT5 keratin 5, type II
LAMP3 lysosomal-associated membrane protein 3
LDHB lactate dehydrogenase B
LEF1 lymphoid enhancer-binding factor 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAOA monoamine oxidase A
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MOXD1 monooxygenase, DBH-like 1
MSN moesin
MXRA7 matrix-remodelling associated 7
NPDC1 neural proliferation, differentiation and control, 1
NPTX2 neuronal pentraxin II
NREP neuronal regeneration related protein
NT5E 5'-nucleotidase, ecto (CD73)
PECAM1 platelet/endothelial cell adhesion molecule 1
PLS3 plastin 3
PLVAP plasmalemma vesicle associated protein
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSPH phosphoserine phosphatase
PTCH1 patched 1
R3HDM4 R3H domain containing 4
RABGAP1L RAB GTPase activating protein 1-like
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SDC2 syndecan 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY4 sprouty homolog 4 (Drosophila)
SSR4 signal sequence receptor, delta
STEAP1 six transmembrane epithelial antigen of the prostate 1
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TGFA transforming growth factor, alpha
TMEM204 transmembrane protein 204
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPD52 tumor protein D52
TRIB2 tribbles pseudokinase 2
TXNIP thioredoxin interacting protein
VIM vimentin

decreased expression

Symbol Name
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
CALML5 calmodulin-like 5
CCNA2 cyclin A2
CDC123 cell division cycle 123
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGR3 early growth response 3
FOXO3 forkhead box O3
GATA3 GATA binding protein 3
GDI2 GDP dissociation inhibitor 2
GREB1 growth regulation by estrogen in breast cancer 1
GRWD1 glutamate-rich WD repeat containing 1
GYG1 glycogenin 1
H2AFX H2A histone family, member X
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGF1R insulin-like growth factor 1 receptor
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JADE2 jade family PHD finger 2
KRT7 keratin 7, type II
MAPK6 mitogen-activated protein kinase 6
MELK maternal embryonic leucine zipper kinase
MLPH melanophilin
MYBPC1 myosin binding protein C, slow type
NET1 neuroepithelial cell transforming 1
NOL11 nucleolar protein 11
NOTCH2 notch 2
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
OPN3 opsin 3
PCNA proliferating cell nuclear antigen
PEG10 paternally expressed 10
S100P S100 calcium binding protein P
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBL1X transducin (beta)-like 1X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLR4 toll-like receptor 4
TMEM176B transmembrane protein 176B
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNNT1 troponin T type 1 (skeletal, slow)
TNS3 tensin 3
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TSC22D2 TSC22 domain family, member 2
TSPYL5 TSPY-like 5
UGDH UDP-glucose 6-dehydrogenase
XBP1 X-box binding protein 1
Funding