BRD-K92571446_WZ-3105_MCF7_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K92571446_WZ-3105_MCF7_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
BIN1 bridging integrator 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COMP cartilage oligomeric matrix protein
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFA6 defensin, alpha 6, Paneth cell-specific
E2F2 E2F transcription factor 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMX2 empty spiracles homeobox 2
ENO2 enolase 2 (gamma, neuronal)
EPHB2 EPH receptor B2
FAM171A1 family with sequence similarity 171, member A1
FOLR1 folate receptor 1 (adult)
GHR growth hormone receptor
GPX3 glutathione peroxidase 3
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM5D lysine (K)-specific demethylase 5D
LOC100272216 uncharacterized LOC100272216
MAB21L2 mab-21-like 2 (C. elegans)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP3 matrix metallopeptidase 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NNT nicotinamide nucleotide transhydrogenase
NPR3 natriuretic peptide receptor 3
OLFM4 olfactomedin 4
PAX8 paired box 8
PCP4 Purkinje cell protein 4
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB4 phospholipase C, beta 4
PRAME preferentially expressed antigen in melanoma
RHOBTB3 Rho-related BTB domain containing 3
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SORD sorbitol dehydrogenase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK4 serine peptidase inhibitor, Kazal type 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPP1 secreted phosphoprotein 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STXBP1 syntaxin binding protein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM47 transmembrane protein 47
TPCN1 two pore segment channel 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ARID4B AT rich interactive domain 4B (RBP1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ASF1A anti-silencing function 1A histone chaperone
BAMBI BMP and activin membrane-bound inhibitor
BMP2 bone morphogenetic protein 2
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHN1 chimerin 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFNA1 ephrin-A1
EIF5 eukaryotic translation initiation factor 5
ELF1 E74-like factor 1 (ets domain transcription factor)
ESR1 estrogen receptor 1
EVI2A ecotropic viral integration site 2A
FASTKD5 FAST kinase domains 5
GATA3 GATA binding protein 3
GSPT2 G1 to S phase transition 2
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KLHL9 kelch-like family member 9
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM5 minichromosome maintenance complex component 5
MED13 mediator complex subunit 13
MTF2 metal response element binding transcription factor 2
NFIL3 nuclear factor, interleukin 3 regulated
NOL11 nucleolar protein 11
NRIP1 nuclear receptor interacting protein 1
NXT1 nuclear transport factor 2-like export factor 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PER2 period circadian clock 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
QKI QKI, KH domain containing, RNA binding
RAP2B RAP2B, member of RAS oncogene family
RBM15 RNA binding motif protein 15
RBM34 RNA binding motif protein 34
RFC2 replication factor C (activator 1) 2, 40kDa
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SERTAD2 SERTA domain containing 2
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SMG8 SMG8 nonsense mediated mRNA decay factor
SNRK SNF related kinase
SOX4 SRY (sex determining region Y)-box 4
SPRED2 sprouty-related, EVH1 domain containing 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TF transferrin
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TSKU tsukushi, small leucine rich proteoglycan
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZEB1 zinc finger E-box binding homeobox 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF281 zinc finger protein 281
ZNF394 zinc finger protein 394
Funding