BRD-K93023739_IKK Inhibitor X_NCIH508_6.0_h_6.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

199 genes differentially expressed following the BRD-K93023739_IKK Inhibitor X_NCIH508_6.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ANO1 anoctamin 1, calcium activated chloride channel
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASPN asporin
BEX1 brain expressed, X-linked 1
CALR calreticulin
CCND2 cyclin D2
CLEC11A C-type lectin domain family 11, member A
COL6A2 collagen, type VI, alpha 2
COMP cartilage oligomeric matrix protein
DAPK1 death-associated protein kinase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSG3 desmoglein 3
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FASN fatty acid synthase
FBN2 fibrillin 2
FMOD fibromodulin
FOXO3 forkhead box O3
FST follistatin
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
KLK5 kallikrein-related peptidase 5
KRT6B keratin 6B, type II
MFSD10 major facilitator superfamily domain containing 10
MGP matrix Gla protein
MMP11 matrix metallopeptidase 11
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OLFML3 olfactomedin-like 3
PDZK1IP1 PDZK1 interacting protein 1
PENK proenkephalin
PI3 peptidase inhibitor 3, skin-derived
PLAU plasminogen activator, urokinase
PRSS2 protease, serine, 2 (trypsin 2)
PRTN3 proteinase 3
PXDN peroxidasin
RAB2A RAB2A, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS1 regulator of G-protein signaling 1
RNH1 ribonuclease/angiogenin inhibitor 1
S100A8 S100 calcium binding protein A8
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLPI secretory leukocyte peptidase inhibitor
SPON2 spondin 2, extracellular matrix protein
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
SRSF5 serine/arginine-rich splicing factor 5
TEX10 testis expressed 10
VIM vimentin
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACTN1 actinin, alpha 1
ADGRE5 adhesion G protein-coupled receptor E5
ADIPOQ adiponectin, C1Q and collagen domain containing
AHR aryl hydrocarbon receptor
ALCAM activated leukocyte cell adhesion molecule
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BCL6 B-cell CLL/lymphoma 6
BIRC3 baculoviral IAP repeat containing 3
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL19 chemokine (C-C motif) ligand 19
CCNB2 cyclin B2
CCND3 cyclin D3
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CDK4 cyclin-dependent kinase 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLIC5 chloride intracellular channel 5
CLINT1 clathrin interactor 1
COCH cochlin
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTSS cathepsin S
CXCL13 chemokine (C-X-C motif) ligand 13
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DARS aspartyl-tRNA synthetase
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DST dystonin
EAPP E2F-associated phosphoprotein
EBNA1BP2 EBNA1 binding protein 2
EGR3 early growth response 3
EIF5B eukaryotic translation initiation factor 5B
ELOVL5 ELOVL fatty acid elongase 5
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FAM13A family with sequence similarity 13, member A
G0S2 G0/G1 switch 2
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GDF15 growth differentiation factor 15
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSN gelsolin
HACD2 3-hydroxyacyl-CoA dehydratase 2
HBB hemoglobin, beta
HECA headcase homolog (Drosophila)
HEXIM1 hexamethylene bis-acetamide inducible 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB11 heat shock protein family B (small), member 11
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDS iduronate 2-sulfatase
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIF2C kinesin family member 2C
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
LEF1 lymphoid enhancer-binding factor 1
LIMS1 LIM and senescent cell antigen-like domains 1
LPAR1 lysophosphatidic acid receptor 1
LRP10 low density lipoprotein receptor-related protein 10
LTF lactotransferrin
LXN latexin
LY75 lymphocyte antigen 75
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MOB1A MOB kinase activator 1A
MPZL1 myelin protein zero-like 1
MRPL19 mitochondrial ribosomal protein L19
MSH6 mutS homolog 6
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NAMPT nicotinamide phosphoribosyltransferase
NEFH neurofilament, heavy polypeptide
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OAT ornithine aminotransferase
OLFM1 olfactomedin 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG10 paternally expressed 10
PIP prolactin-induced protein
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PIR pirin (iron-binding nuclear protein)
PLA2G16 phospholipase A2, group XVI
PLAC8 placenta-specific 8
PPARG peroxisome proliferator-activated receptor gamma
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRPF4 pre-mRNA processing factor 4
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAB40B RAB40B, member RAS oncogene family
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RNF6 ring finger protein (C3H2C3 type) 6
RRP1B ribosomal RNA processing 1B
S100A13 S100 calcium binding protein A13
SAR1B secretion associated, Ras related GTPase 1B
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEH1L SEH1-like (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A46 solute carrier family 25, member 46
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMS spermine synthase
SPAG1 sperm associated antigen 1
SYBU syntabulin (syntaxin-interacting)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIMP4 TIMP metallopeptidase inhibitor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM106B transmembrane protein 106B
TMEM165 transmembrane protein 165
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM22 tripartite motif containing 22
TSPAN8 tetraspanin 8
TXNDC9 thioredoxin domain containing 9
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP1 ubiquitin specific peptidase 1
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WSB2 WD repeat and SOCS box containing 2
XBP1 X-box binding protein 1
YME1L1 YME1-like 1 ATPase
Funding