BRD-K93034159_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K93034159_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CCNL1 cyclin L1
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CPA3 carboxypeptidase A3 (mast cell)
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CTSK cathepsin K
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF4A1 eukaryotic translation initiation factor 4A1
FAS Fas cell surface death receptor
FBLN1 fibulin 1
FDXR ferredoxin reductase
FGFR2 fibroblast growth factor receptor 2
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HSPA2 heat shock 70kDa protein 2
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IL6 interleukin 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT8 keratin 8, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MXRA5 matrix-remodelling associated 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
PHLDA3 pleckstrin homology-like domain, family A, member 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RRAD Ras-related associated with diabetes
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SDC4 syndecan 4
SESN1 sestrin 1
SFRP4 secreted frizzled-related protein 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SRSF7 serine/arginine-rich splicing factor 7
STC2 stanniocalcin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TIGAR TP53 induced glycolysis regulatory phosphatase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOB1 transducer of ERBB2, 1
TRIM22 tripartite motif containing 22
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZMAT3 zinc finger, matrin-type 3
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADGRF5 adhesion G protein-coupled receptor F5
AKR1C3 aldo-keto reductase family 1, member C3
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FAM64A family with sequence similarity 64, member A
GPSM2 G-protein signaling modulator 2
GTSE1 G-2 and S-phase expressed 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IQGAP2 IQ motif containing GTPase activating protein 2
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
MGLL monoglyceride lipase
MKI67 marker of proliferation Ki-67
NDC80 NDC80 kinetochore complex component
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NTS neurotensin
PBK PDZ binding kinase
PECAM1 platelet/endothelial cell adhesion molecule 1
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
RBM47 RNA binding motif protein 47
RHOBTB3 Rho-related BTB domain containing 3
RPS11 ribosomal protein S11
S100A7 S100 calcium binding protein A7
SLAMF7 SLAM family member 7
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SPC25 SPC25, NDC80 kinetochore complex component
TM4SF1 transmembrane 4 L six family member 1
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S