BRD-K93034159_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

58 genes differentially expressed following the BRD-K93034159_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
BAG3 BCL2-associated athanogene 3
CCNE2 cyclin E2
CRIP1 cysteine-rich protein 1 (intestinal)
DCK deoxycytidine kinase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EGR3 early growth response 3
ELOVL5 ELOVL fatty acid elongase 5
GCH1 GTP cyclohydrolase 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
KLF4 Kruppel-like factor 4 (gut)
SCGB2A2 secretoglobin, family 2A, member 2
TUBB2A tubulin, beta 2A class IIa
ZNF131 zinc finger protein 131

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF5A eukaryotic translation initiation factor 5A
EXT1 exostosin glycosyltransferase 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GATA2 GATA binding protein 2
GATA6 GATA binding protein 6
GLIPR1 GLI pathogenesis-related 1
GPSM2 G-protein signaling modulator 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IPO13 importin 13
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MKI67 marker of proliferation Ki-67
MYOF myoferlin
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
PLK1 polo-like kinase 1
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS5 regulator of G-protein signaling 5
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
TNNT1 troponin T type 1 (skeletal, slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
Funding