BRD-K93034159_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K93034159_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AGR2 anterior gradient 2
AMIGO2 adhesion molecule with Ig-like domain 2
CCNE2 cyclin E2
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS2 dehydrogenase/reductase (SDR family) member 2
EMP1 epithelial membrane protein 1
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GSTM3 glutathione S-transferase mu 3 (brain)
KRT7 keratin 7, type II
MUC5B mucin 5B, oligomeric mucus/gel-forming
SEPP1 selenoprotein P, plasma, 1
SRGN serglycin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BMP4 bone morphogenetic protein 4
BPTF bromodomain PHD finger transcription factor
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNB2 cyclin B2
CCNF cyclin F
CD38 CD38 molecule
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK6 cyclin-dependent kinase 6
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CKS2 CDC28 protein kinase regulatory subunit 2
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNM1L dynamin 1-like
GTSE1 G-2 and S-phase expressed 1
HIST1H2BG histone cluster 1, H2bg
HMMR hyaluronan-mediated motility receptor (RHAMM)
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRAS Kirsten rat sarcoma viral oncogene homolog
LCN2 lipocalin 2
MKI67 marker of proliferation Ki-67
MSMB microseminoprotein, beta-
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PCP4 Purkinje cell protein 4
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS4Y1 ribosomal protein S4, Y-linked 1
TARP TCR gamma alternate reading frame protein
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRD T cell receptor delta locus
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
Funding