BRD-K93123848_RAF 265_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

197 genes differentially expressed following the BRD-K93123848_RAF 265_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADD3 adducin 3 (gamma)
AKR1C3 aldo-keto reductase family 1, member C3
AMT aminomethyltransferase
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARMCX2 armadillo repeat containing, X-linked 2
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BEX4 brain expressed, X-linked 4
BST2 bone marrow stromal cell antigen 2
CASP10 caspase 10, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CRISP3 cysteine-rich secretory protein 3
CSRP1 cysteine and glycine-rich protein 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DMBT1 deleted in malignant brain tumors 1
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM117A family with sequence similarity 117, member A
FAM63A family with sequence similarity 63, member A
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOLR1 folate receptor 1 (adult)
GAB2 GRB2-associated binding protein 2
GAS6 growth arrest-specific 6
GBP2 guanylate binding protein 2, interferon-inducible
GPA33 glycoprotein A33 (transmembrane)
GUSBP3 glucuronidase, beta pseudogene 3
H1FX H1 histone family, member X
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMG20B high mobility group 20B
HMOX1 heme oxygenase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KIAA1598
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LIMCH1 LIM and calponin homology domains 1
LIMK2 LIM domain kinase 2
LY96 lymphocyte antigen 96
MAP7 microtubule-associated protein 7
MATN2 matrilin 2
MEIS1 Meis homeobox 1
MVP major vault protein
MXRA5 matrix-remodelling associated 5
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
OSR2 odd-skipped related transciption factor 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PEG3 paternally expressed 3
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PRAF2 PRA1 domain family, member 2
PSAT1 phosphoserine aminotransferase 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SELENBP1 selenium binding protein 1
SERF2 small EDRK-rich factor 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SVIL supervillin
TPP1 tripeptidyl peptidase I
UBA7 ubiquitin-like modifier activating enzyme 7
VAT1 vesicle amine transport 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)
YME1L1 YME1-like 1 ATPase

decreased expression

Symbol Name
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP3 aquaporin 3 (Gill blood group)
ATAD2 ATPase family, AAA domain containing 2
BHMT betaine--homocysteine S-methyltransferase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BZW1 basic leucine zipper and W2 domains 1
CCNA2 cyclin A2
CCND1 cyclin D1
CCND3 cyclin D3
CD36 CD36 molecule (thrombospondin receptor)
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CRCT1 cysteine-rich C-terminal 1
CTPS1 CTP synthase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFHD2 EF-hand domain family, member D2
EGFR epidermal growth factor receptor
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F13A1 coagulation factor XIII, A1 polypeptide
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3C family with sequence similarity 3, member C
FERMT1 fermitin family member 1
FHL1 four and a half LIM domains 1
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GEM GTP binding protein overexpressed in skeletal muscle
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LOXL2 lysyl oxidase-like 2
LTF lactotransferrin
LYPD3 LY6/PLAUR domain containing 3
MCM3 minichromosome maintenance complex component 3
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTCL1 microtubule crosslinking factor 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAX5 paired box 5
PDLIM1 PDZ and LIM domain 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PSD3 pleckstrin and Sec7 domain containing 3
PUS7 pseudouridylate synthase 7 (putative)
RAD23B RAD23 homolog B (S. cerevisiae)
RAN RAN, member RAS oncogene family
RCC1 regulator of chromosome condensation 1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SACS sacsin molecular chaperone
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPHK1 sphingosine kinase 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
STK17A serine/threonine kinase 17a
STMN1 stathmin 1
STX1A syntaxin 1A (brain)
TACC1 transforming, acidic coiled-coil containing protein 1
TACSTD2 tumor-associated calcium signal transducer 2
TCL1A T-cell leukemia/lymphoma 1A
TEX10 testis expressed 10
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican
VDAC1 voltage-dependent anion channel 1
Funding