BRD-K93123848_RAF 265_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

58 genes differentially expressed following the BRD-K93123848_RAF 265_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BASP1 brain abundant, membrane attached signal protein 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP6 dual specificity phosphatase 6
EFS embryonal Fyn-associated substrate
F2RL1 coagulation factor II (thrombin) receptor-like 1
FASN fatty acid synthase
FOS FBJ murine osteosarcoma viral oncogene homolog
GAB2 GRB2-associated binding protein 2
HBB hemoglobin, beta
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
LMO3 LIM domain only 3 (rhombotin-like 2)
MAP2K6 mitogen-activated protein kinase kinase 6
MCF2L MCF.2 cell line derived transforming sequence-like
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NRCAM neuronal cell adhesion molecule
PHGDH phosphoglycerate dehydrogenase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PYCR1 pyrroline-5-carboxylate reductase 1
RAB4A RAB4A, member RAS oncogene family
RPS4Y1 ribosomal protein S4, Y-linked 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TRIM13 tripartite motif containing 13
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
AREG amphiregulin
ASPN asporin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CFB complement factor B
CLTB clathrin, light chain B
DHFR dihydrofolate reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GEM GTP binding protein overexpressed in skeletal muscle
GPX3 glutathione peroxidase 3
IGFBP7 insulin-like growth factor binding protein 7
JAG1 jagged 1
MGP matrix Gla protein
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
PCNA proliferating cell nuclear antigen
PEG3 paternally expressed 3
PTPN3 protein tyrosine phosphatase, non-receptor type 3
RAD23B RAD23 homolog B (S. cerevisiae)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
S100A9 S100 calcium binding protein A9
SFRP4 secreted frizzled-related protein 4
SPRR1B small proline-rich protein 1B
TIMP3 TIMP metallopeptidase inhibitor 3
WT1 Wilms tumor 1
Funding